Project Grant R01AG100645
Award Date 9/1/26
Completion Date 7/31/31
Dollars Obligated $663K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $681,908 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate protective mechanisms of UFM1-dependent IRE1 signaling in tauopathies, with work performance in San Francisco, California through November 30, 2030. The project addresses tau protein aggregation in Alzheimer's disease and related tauopathies by elucidating molecular mechanisms linking the ufmylation pathway...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $1,613,176 on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the impact of M6A RNA modifications in Alzheimer's disease and tauopathies. The research will characterize N6-methyladenosine (M6A) RNA modifications and their downstream functional consequences in post-mortem brain tissue from subjects with Alzheimer's disease and other tauopathies, leveraging...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Regents of the University of California, San Francisco $194,573 on February 20, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanisms of microglial-mediated sex-based differences in tauopathy. The recipient will conduct basic research examining how gonadal hormones contribute to sex-based differences in tau-related neurodegeneration through their effects on microglia, the...
- The National Institute on Aging awarded the University of California, Los Angeles $126,063 on August 5, 2026, under the Aging Research program (CFDA 93.866) to determine the atomic structures of amyloid-beta and tau oligomers and to characterize the molecular interaction between amyloid-beta and the TREM2 receptor on microglia. The award is classified as a Project Grant, specifically a K99/R00 award. The research develops a novel oligomer structure determination pipeline incorporating native...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded $152,600 to Baylor College of Medicine on December 26, 2026, under the Aging Research program (CFDA 93.866) to investigate the synergistic mechanisms of tau and amyloid-beta aggregation in Alzheimer's disease pathology. The project, titled "Synergy in Condensation: Tau and AB in Alzheimer's Disease," employs advanced biophysical techniques including fluorescence lifetime imaging microscopy and microfluidic modulation infrared spectroscopy to...
- The National Institute on Aging awarded New York University $422,297 under the Aging Research program (CFDA 93.866) on February 15, 2026, to investigate mechanisms of dysregulated protein synthesis in human neurons carrying frontotemporal dementia–associated tau mutations. The project uses human induced pluripotent stem cell–derived neurons bearing FTD-associated tau mutations to model how pathogenic tau disrupts protein synthesis. In the first aim, researchers will determine the impact of...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded UC San Diego a $437,250 Project Grant effective May 15, 2025, through April 30, 2027, under the Aging Research program (CFDA 93.866). This award funds the development of innovative imaging tools to visualize tau protein in multiple conformational states relevant to Alzheimer's disease pathogenesis. Specifically, the project will develop a peptide-based probe utilizing aggregation-induced emission (AIE) technology...
- The National Institute on Aging awarded the University of Florida $422,125 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how pathological tau protein affects RNA translation and neuronal function in tauopathies, including progressive supranuclear palsy and Alzheimer's disease. The research will identify RNA transcripts that bind to tau in primary tauopathies, characterize newly translated proteins in the presence of pathological tau, and examine tau-RNA...