Project Grant R01AG100345
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of California, Irvine $3.22M under the Aging Research program (CFDA 93.866) for a project grant commencing September 15, 2025, with completion scheduled for August 31, 2029. This project will deliver biomedical research services focused on understanding the role of the retrosplenial cortex in Alzheimer's disease (AD) pathogenesis. The research will establish the mechanisms by which neuronal hyperexcitability...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging, within the National Institutes of Health and the Department of Health and Human Services, awarded the University of California Irvine $739,365 on September 15, 2026, under the Aging Research program (CFDA 93.866, Project Grant R01AG098878) to develop and evaluate structure-guided active and passive beta-amyloid immunotherapies targeting early, non-fibrillar assemblies in Alzheimer's disease. The project develops vaccines and monoclonal antibodies directed against...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of California, Irvine a $2.49 million Project Grant under the Aging Research program (CFDA 93.866) for research on circuit vulnerability in entorhinal cortex tauopathy models of Alzheimer's disease. The award, effective September 15, 2025, through August 31, 2029, will fund scientific research to identify neuronal cell types vulnerable to tau pathology in the lateral and medial entorhinal cortex using two...
- The National Institute on Aging, an office of the National Institutes of Health, awarded the University of California, Davis $683,331 under the Aging Research program (CFDA 93.866) on September 1, 2026, to identify and validate causal risk genes and proteins contributing to Alzheimer's disease and its neuropsychiatric symptoms. The research integrates genome-wide association study (GWAS) findings with functional omics data from post-mortem brain tissues to pinpoint proteins mediating Alzheimer's...
- The National Institute on Aging awarded the University of California, Los Angeles $623,176 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on modifiable risk factors for Alzheimer's disease and related dementias among individuals aged 90 and older. The research triangulates evidence across four data sources—the LifeAfter90 Study (1,397 participants, all aged 90), the 90+ Study (1,630 participants, all aged 90), the Health and Retirement Study (3,359...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded the University of California Irvine $1.238 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate longitudinal relationships between Alzheimer's disease pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The project uses multimodal neuroimaging combining polysomnography, high-density electroencephalography, and high-resolution structural magnetic resonance imaging of...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging awarded the University of California, Davis $586,378 on August 15, 2026, under the Aging Research program (CFDA 93.866) to characterize metabolic and lipidomic signatures of microglia in Alzheimer's disease using spatial metabolomics and lipidomics workflows. The research employs MALDI mass spectrometry imaging combined with highly multiplexed immunofluorescence to provide direct metabolite information of microglia in situ, addressing the heterogeneity of...
The National Institute on Aging awarded the University of California Irvine $636,124 for Project Grant R01AG100345 on September 2, 2026, under the Aging Research program (CFDA 93.866). The award funds multi-omic characterization of molecular pathways driving vulnerability and resilience to Alzheimer's disease in the oldest-old population (age 90 and above). The research employs an integrative multi-omic approach including single-nucleus RNA and ATAC sequencing, spatial transcriptomics, and whole-genome sequencing on the 90+ Study cohort to define cell-type-specific transcriptional and spatial signatures, determine epigenomic landscapes and regulatory networks, and identify how genetic variants influence molecular architecture in relation to diverse cognitive outcomes. The project aims to identify novel therapeutic targets by revealing new mechanisms of Alzheimer's disease pathogenesis in extreme aging. Performance occurs in California. The period of performance extends from the award date through May 31, 2031. UCI functions as a publicly funded research institution and operates as a prime recipient on the overwhelming majority of its federal awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $636.1k | 9/1/26 |