Project Grant R01AG098878
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $356,174 to The Regents of the University of California, San Francisco (UCSF) to conduct in vivo testing of structure-based vaccine candidates targeting Alzheimer's disease. The goal is to determine the efficacy of an active immunization strategy in preserving cognitive and neural function by slowing the formation of amyloid-beta or tau protein aggregation in the brain. The research will use...
- The National Institute on Aging awarded the University of California, Los Angeles $126,063 on August 5, 2026, under the Aging Research program (CFDA 93.866) to determine the atomic structures of amyloid-beta and tau oligomers and to characterize the molecular interaction between amyloid-beta and the TREM2 receptor on microglia. The award is classified as a Project Grant, specifically a K99/R00 award. The research develops a novel oligomer structure determination pipeline incorporating native...
- The National Institute on Aging awarded the University of California Irvine $636,124 for Project Grant R01AG100345 on September 2, 2026, under the Aging Research program (CFDA 93.866). The award funds multi-omic characterization of molecular pathways driving vulnerability and resilience to Alzheimer's disease in the oldest-old population (age 90 and above). The research employs an integrative multi-omic approach including single-nucleus RNA and ATAC sequencing, spatial transcriptomics, and...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $442,750 to the University of California, Davis on September 1, 2026, under the Aging Research program (CFDA 93.866, assistance type: Project Grant) to investigate galectin-12's role in neuroinflammation and Alzheimer's disease progression. The funded research examines how metabolic stress triggers Alzheimer's disease by enhancing inflammation, with a focus on lipid droplet...
- The National Institute on Aging, a division of the Department of Health and Human Services National Institutes of Health, awarded Advantage Therapeutics, Inc. $3.749 million on September 20, 2025, under the Aging Research program (CFDA 93.866) to perform IND-enabling studies on a small-molecule immunomodulating compound for Alzheimer's disease. The recipient will conduct preclinical and IND-enabling studies on a disease-modifying therapeutic designed to reduce brain inflammation and restore...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded the University of California, San Diego $408,012 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop methods for improving central nervous system pharmacokinetics of targeted protein degraders through specialized assay workflows and prodrug chemistries. The research will establish dual-functional molecules that hijack endogenous molecular transport pathways to cross the blood-brain barrier, with early-stage application to...
- The National Institute on Aging awarded New York University $712,578 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a prospective study identifying viral infections associated with cognition decline and Alzheimer's disease risk across three prospective cohorts. The award supports comprehensive serologic profiling using VirScan, a bacteriophage immunoprecipitation sequencing technology, to detect immune responses to human viruses and analyze antiviral antibodies in...
The National Institute on Aging, within the National Institutes of Health and the Department of Health and Human Services, awarded the University of California Irvine $739,365 on September 15, 2026, under the Aging Research program (CFDA 93.866, Project Grant R01AG098878) to develop and evaluate structure-guided active and passive beta-amyloid immunotherapies targeting early, non-fibrillar assemblies in Alzheimer's disease. The project develops vaccines and monoclonal antibodies directed against structurally defined beta-hairpin and oligomer-mimetic antigens, with the goal of safely engaging early amyloid-beta conformations to prevent or reverse Alzheimer's-like pathology while minimizing vascular complications such as amyloid-related imaging abnormalities. Preliminary studies demonstrate that the beta-hairpin peptide 2AM-L and the covalently stabilized oligomer mimetic 2AT-L reproduce structural features of early amyloid-beta assemblies and elicit antibodies that selectively bind disease-relevant pathology. The corresponding monoclonal antibodies F20-5 and F20-12 recognize conformational epitopes on these antigens. Performance takes place in Irvine, California, with a period of performance from September 15, 2026, through June 30, 2031. This is a Project Grant, an assistance type within the National Institute on Aging's broader mission to support biomedical and behavioral research directed toward understanding aging and preventing Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $739.4k | 8/31/26 |