Project Grant R01AG100153
- Federal Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $463,375 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on June 15, 2026, with completion targeted for May 31, 2028. The grant supports research investigating how aging alters the lung tumor microenvironment (TME) and drives non-small cell lung cancer (NSCLC) evolution and treatment resistance. Specifically, the research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $463,625 under the Aging Research program (CFDA 93.866) for the period September 1, 2025, through August 31, 2027. The grant supports research investigating the effects of aging on the lung adenocarcinoma tumor microenvironment, with particular focus on understanding age-related variations in immunotherapy response. The project deliverables include: (1)...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Fred Hutchinson Cancer Center a $1.56 million Project Grant under the Aging Research program (CFDA 93.866) on April 15, 2026, to investigate immune aging phenotypes in adult survivors of childhood hematologic malignancies through June 2031. The research will employ high-dimensional immunological approaches to characterize distinct age-associated immune cell alterations in long-term cancer survivors and correlate these...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $1.57 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 1, 2026, with a completion date of May 31, 2031. The award supports epidemiological research investigating the relationship between clonal hematopoiesis of indeterminate potential (CHIP)—an age-related phenomenon involving somatic mutations in blood cells—and aging outcomes in older women. The...
- Federal Project Grant Award Summary The National Institute on Aging awarded Washington University a $1.75 million Project Grant under the Aging Research program (CFDA 93.866) on August 5, 2025, with a completion date of April 30, 2030. This grant supports basic and translational research investigating the role of senescent cancer-associated fibroblasts (SENCAFs) in breast cancer progression, particularly as it relates to age-related changes in the tumor microenvironment. The research will employ...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $393,750 to the University of California, Los Angeles (UCLA) on September 22, 2025, under the Aging Research program (CFDA 93.866) to conduct a prospective cohort study investigating how aggressive cancer treatments affect physical function in older adults with gastroesophageal cancer (GEC). The research will enroll patients aged 60 years and older who are initiating systemic treatment (chemotherapy,...
- Federal Grant Award Summary The University of Pittsburgh received a $3.1 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the mechanistic relationship between persistent DNA damage-induced immune responses and aging. Specifically, the research examines how the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes)...
- Federal Grant Award Summary The University of Florida, Division of Sponsored Research, received a $383,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025, through July 31, 2027. This research project focuses on characterizing age-related changes to the senescence-associated secretory phenotype (SASP) of thyroid tissue in papillary thyroid carcinoma (PTC). The deliverables include scientific research aimed...
- Federal Grant Award Summary The National Institute on Aging awarded a $157,572 Project Grant to the University of Chicago (Award Date: July 1, 2026; Completion Date: April 30, 2031) under the Aging Research program (CFDA 93.866) to develop precision dosing models for metastatic prostate cancer (MPC) treatment in older adults. The research will deliver evidence-based, individualized dosing guidelines for androgen receptor signaling inhibitors (ARSIs) by validating the relationship between ARSI...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $737,261 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective July 1, 2026, through March 31, 2031. This award supports research to elucidate the functional consequences of TERT (telomerase reverse transcriptase) missense rare variants and investigate the relationship between germline-encoded telomere dysfunction and age-related somatic clonal hematopoiesis. The...
The National Institute on Aging (NIA) awarded a Project Grant totaling $707,102 to H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., effective July 1, 2026, through March 31, 2031, under the Aging Research program (CFDA 93.866). This research project addresses therapeutic resistance in lung cancer among elderly patients by investigating age-induced mechanisms that compromise treatment efficacy. The primary research deliverable is scientific investigation into how age-related systemic metabolic changes—specifically the circulatory accumulation of glucocorticoid hormones—drive resistance to chemotherapy and targeted therapies in KRAS-driven lung cancer, with particular focus on the tumor microenvironment. The project is structured around three specific research aims that will evaluate the dependence of age-induced intrinsic therapy resistance on glucocorticoid signaling pathways. This award supports fundamental biomedical research aligned with the NIA's mission to advance understanding of aging processes and age-related diseases. The research addresses a significant gap in preclinical and clinical oncology by incorporating aging as a primary variable in therapeutic resistance studies, with potential implications for improving lung cancer treatment outcomes in elderly populations. The award reflects the Aging Research program's support for mechanistic studies and represents typical Project Grant funding within the NIA portfolio, which comprises 95 percent of awards under this listing.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $707.1k | 6/26/26 |