Project Grant R01AG099844
- Federal Project Grant Award Summary The National Institute on Aging has awarded $3.45M to The Trustees of Columbia University in the City of New York to conduct research on the molecular mechanisms and genetic basis of human ovarian aging under the Aging Research program (CFDA 93.866). The four-year project, initiated September 1, 2025 and concluding August 31, 2029, will investigate how the ovary ages at an accelerated rate compared to other human tissues and identify causal genetic factors...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Oklahoma Medical Research Foundation a $2.6 million Project Grant under the Aging Research program (CFDA 93.866) effective September 15, 2025, with a completion date of August 31, 2029. The research focuses on investigating the role of mitochondrial Adenosine Monophosphate-activated Protein Kinase (AMPK) signaling in neuronal function and Alzheimer's disease (AD) pathology. The award supports scientific research designed...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pittsburgh a $3.1 million Project Grant under the Aging Research program (CFDA 93.866) for the period September 1, 2025, through August 31, 2029. The research project investigates a novel protective immune mechanism in aging and DNA repair-deficient conditions. The research deliverables include scientific investigation into how persistent DNA damage induces beneficial immune responses through the NOD-like...
- Federal Grant Award Summary The Buck Institute for Research on Aging received a Project Grant award of $809,486 from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2031. The award funds research investigating the role of Oxidation Resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's Disease and Related Dementias (ADRD). The research leverages multiple model systems, including Drosophila...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pittsburgh a $428,123 Project Grant effective February 1, 2026, through January 31, 2028, under the Aging Research program (CFDA 93.866). This research project aims to investigate the mechanisms of aging in chondrocytes—the primary cells in articular cartilage—with the objective of developing therapeutic interventions to enhance cartilage regeneration and reduce osteoarthritis (OA) risk in older...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $462,000 Project Grant award dated August 15, 2025, from the National Institute on Aging under the Aging Research program (CFDA 93.866). The award supports a two-year research initiative (concluding July 31, 2027) investigating the regulation of thymus function and aging through sympathetic nervous system (SNS) mechanisms. The research addresses the age-dependent decline in thymic structure and...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $699,344 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion targeted for August 31, 2027. This research initiative investigates the relationship between surgical stress, sex-dependent vulnerabilities, and aging hallmarks, with a focus on understanding physiologic resilience—the capacity of biological systems to restore...
- Federal Grant Award Summary The Oklahoma Medical Research Foundation (OMRF) received a $426,250 Project Grant awarded on August 15, 2025, by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, which extends through July 31, 2030, supports fundamental research into novel pathways of heterochromatin regulation within eukaryotic genomes. The research encompasses two distinct projects: the first investigates...
- The University of Oklahoma Health Sciences Center received a $786,500 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2027. This research grant funds a two-year investigation into the cell-type specific role of melanocortin 4 receptor (MC4R) in inflammation and cognitive decline associated with aging. The research addresses "inflammaging"—chronic, low-grade inflammation linked to...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $647,866 Project Grant to the University of North Carolina at Chapel Hill, effective August 15, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The research initiative, titled "Epigenetic Regulation of Nuclear cGAS Activity in Aging-Related Inflammation," will investigate the molecular mechanisms linking histone acetylation patterns to chronic inflammation in aging. Specifically,...
The National Institute on Aging (NIA) awarded Oklahoma Medical Research Foundation (OMRF) a Project Grant of $711,479 under the Aging Research program (CFDA 93.866) with an award date of March 15, 2026, and completion date of February 28, 2031. This research grant supports a five-year biomedical research initiative investigating the inflammatory and immune mechanisms that drive ovarian tissue aging. The project will deliver scientific research services focused on understanding age-related ovarian dysfunction through mechanistic studies of how innate and adaptive immune components contribute to chronic, low-grade inflammation and structural tissue remodeling in ovarian tissue. The research will examine cellular drivers and signaling mechanisms underlying inflammatory responses in the ovary, with particular emphasis on NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling in granulosa cells and its role in orchestrating a feed-forward inflammatory loop involving tissue-resident macrophages (TRMs) and type 17 T cells. OMRF will deliver research outputs including mechanistic findings on immune-tissue crosstalk, fibrosis pathways, and immune-mediated ovarian dysfunction, employing conditional ablation techniques and functional analysis to isolate the roles of specific cell types in sustaining ovarian inflammation. These research deliverables will advance understanding of aging processes and age-related diseases, consistent with the NIA's mission to support biomedical research directed toward greater understanding of aging and associated health challenges.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $48.2k | 3/16/26 | ||
| Not listed | $663.2k | 3/6/26 |