Project Grant R01AG098667
- The National Institute on Aging awarded Texas A&M University $640,059 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebellar changes in aging and cognitive decline through longitudinal neuroimaging and functional analysis. The project examines how cerebellar structure, white matter circuits, and task-based functional activation change over time in older adults, with particular focus on individuals experiencing subjective cognitive decline—self-reported...
- The National Institute on Aging awarded William Marsh Rice University $100,228 on December 4, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the mental, physical, and immune health effects of negative emotional inertia and childhood trauma in dementia spousal caregivers. The research evaluates the role of emotional inertia—negative emotions that resist change over time—in caregiver self-reported health and immune function. The study assesses whether childhood...
- The National Institute on Aging awarded The Johns Hopkins University $680,637 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a pragmatic clinical trial improving cognitive impairment screening in older adults with diabetes. The funded work develops and validates novel tools using natural language processing and large language models to identify cognitive impairment and Alzheimer's disease and related dementias screening events in electronic health records. The...
- The National Institute on Aging awarded the University of Texas Health Science Center at Houston $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a developmental research project estimating the effectiveness of hearing aid initiation in reducing incident Alzheimer's disease and related dementias among older adults. The recipient will use target trial emulation with real-world data from the Texas All-Payor Claims Database to assess hearing aid effectiveness...
- The National Institute on Aging awarded Posit Science Corporation $1,008,342 on September 20, 2025, under the Aging Research program (CFDA 93.866) to conduct a prospective, double-blind, parallel-arm, active-controlled clinical trial of INHANCE-MCI, a computerized cognitive training program designed to enhance cholinergic neurotransmission and slow cognitive decline in individuals with mild cognitive impairment. The trial will randomize patients to intervention or active control arms and...
- The National Institute on Aging awarded The University of Texas Health Science Center at San Antonio $2,147,145 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct the Rural Microvascular Contributions to Neurocognitive Decline (RURAL-MIND) study. The study deploys portable MRI neuroimaging, AI-driven image analytics, repeated plasma biomarker profiling, and longitudinal cognitive assessments across 4,000 rural residents in high- and lower-risk counties to...
- The National Institute on Aging awarded the University of Washington $1,212,446 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal analysis of multi-omics biomarkers and their association with cognitive decline and dementia. The recipient will leverage serial multi-omics data with deep phenotyping to map mechanisms of cognitive decline and dementia and nominate druggable targets. The work uses two discovery and replication cohorts: the Cardiovascular...
- The National Institute on Aging awarded the University of Texas Medical Branch at Galveston $1.788 million on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the interplay between microglia and tau oligomer polymorphs in cognitive resilience among individuals with Alzheimer's disease neuropathology who remain cognitively intact. The project tests the hypothesis that brain-derived tau oligomers isolated from cognitively resilient individuals exhibit reduced toxicity...
- The National Institute of Nursing Research awarded $430,884 to the University of Texas at Austin on March 23, 2026, under the Nursing Research program (CFDA 93.361) to conduct a feasibility study of MUSIC-4-MS, a 12-week music-based eHealth intervention designed to improve cognition in people living with multiple sclerosis. The study addresses cognitive impairment affecting up to 70 percent of individuals with MS, where early-onset dementia occurs at rates seven times higher than in adults...
- The National Institute on Aging awarded Texas Tech University $447,541 on February 1, 2026, under the Aging Research program (CFDA 93.866, assistance type: Project Grant) to investigate microRNA-driven mitochondrial dysfunction in Alzheimer's disease. The research focuses on validating microRNA PC-5P-12969 as both a biomarker for early Alzheimer's diagnosis and a potential therapeutic target. The recipient will measure microRNA PC-5P-12969 levels in blood, cerebrospinal fluid, and postmortem...
The National Institute on Aging awarded William Marsh Rice University $826,582 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct PROJECT CHROMA, a randomized clinical trial testing a scalable music creativity intervention for mild cognitive impairment. The trial will enroll 210 participants (70 per arm) and compare a six-week active music creativity program—structured composition, improvisation, and collaborative performance—against an active music appreciation course and a passive personalized listening program. Eligibility will be confirmed via telehealth for adults with physician-documented mild cognitive impairment within 12 months or telephone Montreal Cognitive Assessment score of 17 or lower (education-adjusted) with preserved instrumental activities of daily living. Assessments occur at baseline, post-intervention (primary clinical time point), three months (mechanistic and clinical durability), and six months (distal clinical durability for cognition and emotional well-being only). The trial will obtain resting-state functional neuroimaging and morning blood samples at baseline, post-intervention, and three months to measure neural flexibility (indexing brain network adaptability) and inflammatory signaling (interleukin-6, tumor necrosis factor-alpha) and cellular energy metabolism in circulating immune cells as markers of bioenergetic resilience, connecting clinical change to mechanisms relevant to Alzheimer's disease and Alzheimer's disease-related dementias. Work is performed in Houston, Texas. The project period runs through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $826.6k | 8/25/26 |