Project Grant R21AG099208
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $429,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective June 1, 2025, through May 31, 2026. This award supports a 12-month research project investigating the role of metal-responsive transcription factors in neurodegenerative diseases, with a focus on understanding how the protein Metal Regulatory Transcription Factor-1...
- Federal Project Grant Award Summary The University of Texas at Austin received a $438,625 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion targeted for August 31, 2027. The research initiative, titled "Decoding the Heterogeneity of Interneuron Vulnerability in Aging and Alzheimer's Disease: An Ultraplex CLEM Approach," will deliver comprehensive scientific investigation into age-related...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas Medical Branch at Galveston a Project Grant totaling $548,723 under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. This research award supports investigations into the interplay between microglia and tau oligomer polymorphs in cognitive resilience among Alzheimer's disease patients. The research will examine why certain individuals remain...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $654,110 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026, through December 31, 2030. The award supports biomedical research investigating the role of Enhancer of Zeste Homolog 2 (EZH2), an epigenetic modifier, in cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD) pathology. The research focuses on how...
- This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
- Federal Project Grant Award Summary The University of Texas Health Science Center at San Antonio received a $126,597 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 9, 2025, with completion anticipated by August 31, 2028. This award funds the development and evaluation of neuroimaging biomarkers to characterize structural and functional network degeneration in Alzheimer's disease (AD). The research addresses a gap in the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Texas A&M Agrilife Research a $2.17 million Project Grant under the Aging Research program (CFDA 93.866) to investigate the functional role of the BIN1 protein in oligodendrocytes and its contribution to myelin and axonal integrity in Alzheimer's disease (AD). The research will be conducted from September 30, 2025, through August 31, 2029, at the institution's College Station, Texas location. The project addresses a...
- Federal Grant Award Summary The University of Texas at Austin received a $5.34 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025, through August 31, 2029. This award supports research investigating remotely-supervised neuromodulation as an intervention for the logopenic variant of primary progressive aphasia (LVPPA), a neurodegenerative disorder characterized by progressive language decline caused by...
- Federal Project Grant Award Summary The National Institute on Aging awarded $433,125 to The University of Texas Health Science Center at San Antonio on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct exploratory research investigating the relationship between extracellular tau protein and neurogenesis through the Low-Density Lipoprotein Receptor Related Protein 1 (LRP1). The project, with a completion date of August 31, 2027, focuses on understanding how tau...
- Federal Project Grant Award Summary The University of Michigan received a $303,449 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective June 1, 2025 through May 31, 2027. This research initiative will investigate the genomic impact of transposable elements (TEs) in Alzheimer's disease (AD) and related dementias (ADRD) by leveraging large-scale datasets from existing AD research cohorts. The project will develop cloud-based computational...
Texas Tech University received a $447,541 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2028. The award funds research investigating the role of microRNA (miRNA) PC-5P-12969 in Alzheimer's disease (AD) pathology, with the objective of determining whether this miRNA can serve as both a diagnostic biomarker and therapeutic target. The research deliverables include validation of miRNA PC-5P-12969 as a biomarker through analysis of blood, cerebrospinal fluid, and postmortem brain tissue samples from diverse cohorts (TARCC and NIH Neurobiobank), mechanistic studies using induced pluripotent stem cell (iPSC)-derived neurons to examine the miRNA's regulation of two key proteins (GSK3A and APP) and impact on mitochondrial function, and preclinical evaluation of protective effects in an APP NL-G-F knock-in mouse model of AD. The research is expected to advance understanding of miRNA-driven mitochondrial dysfunction in Alzheimer's disease and generate preliminary data supporting potential future therapeutic development. The project addresses a critical gap in AD treatment options by exploring novel molecular mechanisms underlying neurodegeneration and identifying biomarkers that could enable earlier disease detection and intervention strategies in older adult populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $447.5k | 1/30/26 |