Project Grant R01AG098151
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University a $1.23 million Project Grant under the Aging Research program (CFDA 93.866) to develop artificial intelligence-driven virtual screening pipelines for identifying brain-penetrant drug candidates targeting Alzheimer's disease and related dementias (AD/ADRD). The five-year project, running from February 1, 2026, through January 31, 2031, will deliver computational tools and datasets designed to...
- Federal Project Grant Award Summary Purdue University received a $419,005 Project Grant from the National Institute on Aging (CFDA 93.866, Aging Research program) awarded May 15, 2025, with a completion date of April 30, 2027. The grant supports research investigating the epigenome-metabolism nexus as a driver of circadian disruption in Alzheimer's disease. The project examines how alterations in one-carbon metabolism—specifically changes in S-adenosylmethionine (SAM) and...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $1.25 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence (AI)-driven computational and experimental workflow for accelerating small-molecule drug discovery targeting Alzheimer's disease. The award, effective February 15, 2026 through January 31, 2031, supports research aimed at identifying chemical probes...
- Federal Grant Award Summary Purdue University received a $412,632 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2030. The award supports the development of advanced computer-aided synthesis planning (CASP) tools that integrate artificial intelligence with biocatalytic and chemo-enzymatic synthesis methods to accelerate the discovery and production of...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $615,390 Project Grant to the University of California, San Diego, effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This grant supports the development of advanced artificial intelligence (AI) models capable of zero-shot antibody affinity predictions for anti-aging therapeutic applications. The research initiative addresses a critical gap in current AI-driven...
- Federal Grant Award Summary The University of South Florida received a $3.3 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025 through August 31, 2029. This award supports the development of novel peptidomimetic biomaterials designed to inhibit amyloid-beta (Aβ42) aggregation as a therapeutic intervention for Alzheimer's disease. The primary deliverables include the rational design and synthesis of structurally...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $509,413 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project period extending through May 31, 2030. The award supports scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), specifically examining how m6A (N6-methyladenosine) modifications of messenger RNA control microglial...
- Federal Grant Award Summary Northeastern University received a $2.24 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on May 15, 2025, with completion anticipated by February 28, 2030. The grant funds comprehensive proteogenomic profiling research to identify and characterize aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The research integrates advanced proteomic methods with...
- Federal Project Grant Award Summary The National Institute on Aging awarded Washington University a $3.19 million Project Grant (CFDA 93.866 - Aging Research) beginning September 1, 2025, and concluding August 31, 2029, to develop advanced machine learning methods for mapping relationships between Alzheimer's disease (AD) biomarkers and neuropsychiatric outcomes. The project will leverage in-vivo positron emission tomography (PET) imaging and magnetic resonance imaging (MRI) data to...
- Federal Grant Award Summary The University of Pittsburgh received a $664,619 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award supports research to develop multiscale computational models of age-specific neurometabolic coupling—the relationship between neuronal activity and metabolic processes in the brain. This research addresses a critical gap in understanding metabolic...
Federal Grant Award Summary Purdue University received a $1,293,752 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 15, 2026, with completion targeted for January 31, 2031. The award funds development of an integrated artificial intelligence (AI) platform designed to advance peptide drug design for Alzheimer's disease (AD) and related dementias (ADRD). The project delivers generative AI models for sequence- and structure-based peptide design, multimodal AI systems to predict peptide drug-like properties, and high-throughput experimental validation platforms combining microdroplet-based peptide selection technology with in vitro and in vivo assays. The research addresses critical limitations in current AD/ADRD therapeutics by leveraging generative AI to explore the vast chemical space of peptides and identify candidates with improved effectiveness, safety, biocompatibility, and manufacturability compared to existing small-molecule drugs and antibodies. Building on preliminary successes including the development of generative AI models (AMP-GAN and PEP-DIFF) and prototype selection platforms, the project will generate transferable AI models and peptide candidates specifically targeting AD/ADRD-related protein aggregates. These deliverables are positioned to provide the aging research community with novel computational tools and drug-like peptide compounds that address fundamental challenges in peptide permeability and stability for neurological disease treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 2/13/26 |