Project Grant R01AG098026
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of California, San Diego a $498,366 Project Grant under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award supports the development and implementation of a novel platform for single-cell capture, immunolabeling, and high-resolution imaging of peripheral blood mononuclear cells (PBMCs) using arrays of bottomless microscopic conical wells with picoliter...
- Federal Grant Award Summary The National Institute on Aging awarded a $2.22 million Project Grant to the University of California, Irvine under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. This award supports the development and optimization of enhancer adeno-associated virus (AAV) vectors—genetically engineered viral tools designed to provide cell-type-specific genetic access and manipulation capabilities in the brain. The primary...
- Federal Grant Award Summary The National Institute on Aging awarded a $700,795 Project Grant to the University of California, San Diego, effective February 1, 2026 through January 31, 2031, under the Aging Research program (CFDA 93.866). The grant supports the development and deployment of Raman Enhanced Determination of Cell Atlas and Typing (REDCAT), an integrated platform designed to map single-cell metabolic activity in complex lymphoid tissues. The research focuses on understanding thymic...
- Federal Grant Award Summary The University of California, San Diego received a $437,375 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2027. The award supports scientific research investigating the role of NIMA-Related Kinase-7 (NEK7) in suppressing inflammation in the aging heart through regulation of RNA-binding proteins. The research deliverables include experimental studies...
- Federal Project Grant Award Summary The University of California, San Diego received a $3.14 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct comprehensive neuropeptidomics research addressing dysregulation of human brain neuropeptide transmitter systems in Alzheimer's disease pathogenesis. The award, obligated on September 15, 2025, with completion targeted for August 31, 2029, funds research to define the full repertoire of...
- Federal Grant Award Summary The University of California, San Francisco received a $805,573 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025, with a completion date of June 30, 2030. This research initiative investigates the impact of N6-methyladenosine (M6A) RNA modifications in Alzheimer's disease and related tauopathies. The project will deliver comprehensive characterization of M6A-RNA changes and...
- Federal Grant Award Summary The National Institute on Aging awarded University of California, Irvine a $773,816 Project Grant under the Aging Research program (CFDA 93.866) on June 1, 2025, with a completion date of March 31, 2030. This award funds a multi-investigator research initiative investigating cell-type-specific and spatial proteogenomics analysis of aberrant RNA splicing and misfolded proteins in Alzheimer's-related tauopathies. The research team will generate single-cell spatial...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded UC San Diego a $437,250 Project Grant effective May 15, 2025, through April 30, 2027, under the Aging Research program (CFDA 93.866). This award funds the development of innovative imaging tools to visualize tau protein in multiple conformational states relevant to Alzheimer's disease pathogenesis. Specifically, the project will develop a peptide-based probe utilizing aggregation-induced emission (AIE) technology...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $1,079,604 Project Grant to The Regents of the University of California, Berkeley, effective May 15, 2025, through February 28, 2030, under the Aging Research program (CFDA 93.866). This award supports research to discover heterogeneous causal pathophysiology mechanisms in Alzheimer's disease (AD) by developing novel statistical methodologies and applying them across diverse datasets. The project addresses a...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a $1,468,868 Project Grant on January 15, 2026, under the Aging Research program (CFDA 93.866) to support a multi-investigator research initiative examining the brain's role as a neural pacemaker in regulating organismal aging. The research will be conducted through November 30, 2030, at Stanford's California campus. This initiative leverages the killifish model organism—a...
The University of California, San Diego received a $615,390 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2031. This award supports the development of robust zero-shot artificial intelligence (AI) models for anti-aging antibody design. The project delivers three primary research products: (1) generation of diverse antibody-antigen interaction datasets at unprecedented scale; (2) training of advanced AI models using generated data combined with literature and public database information to predict antibody affinities without target-specific training data; and (3) rigorous performance evaluation, benchmarking against state-of-the-art methods, generality testing across diverse antigens, and experimental validation of prediction accuracy. The ultimate deliverable is a computational tool and set of novel antibody candidates targeting therapeutic agents associated with aging and age-related diseases. The research addresses a critical gap in zero-shot antibody affinity prediction by combining synthetic data generation with machine learning model development, with the aim of accelerating antibody discovery and optimization for anti-aging therapeutic applications. This five-year initiative aligns with the NIA's mission to support biomedical research directed toward understanding the aging process and preventing age-related diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $615.4k | 1/16/26 |