Project Grant R01AG097828
- The National Institute on Aging awarded Trustees of Indiana University (doing business as Indiana University Indianapolis) $791,039 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational methods enabling patient-centered prognostic profiling for Alzheimer's disease and related dementias that accounts for individual cognitive resilience in response to neuropathological changes. The work will model each patient's distinct connectome architecture and cognitive...
- The National Institute on Aging awarded the Trustees of Indiana University $1.232 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop AI-driven virtual screening pipelines and computational tools for identifying blood-brain-barrier-penetrant drug candidates against Alzheimer's disease and related dementias. The funded research encompasses three interconnected aims: developing AI-driven virtual screening pipelines incorporating small-molecule foundation...
- The National Institute on Aging awarded Indiana University Indianapolis $109,795 on August 20, 2026, under the Aging Research program (CFDA 93.866) to evaluate amyloid dynamics and cerebral amyloid angiopathy burden. The project examines amyloid plaque redistribution and cerebral amyloid angiopathy development through genetic and pharmacological methods, and tests whether dietary and exercise interventions mitigate cerebral amyloid angiopathy burden. The research evaluates glial-based mechanisms...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Trustees of Indiana University (Indiana University Indianapolis) on April 15, 2026, under the Aging Research program (CFDA 93.866) for development and validation of a humanized SERPINA3 mouse model to advance Alzheimer's disease research. The award funds creation of a transgenic mouse model that expresses human SERPINA3 in an Alzheimer's disease context, enabling in vivo testing of...
- The National Institute on Aging awarded Trustees of Indiana University $674,455 on September 3, 2026, under the Aging Research program (CFDA 93.866) to create the first longitudinal platform tracking home health agency ownership linked to health outcomes for people living with Alzheimer's disease and related dementias. The project will build a data infrastructure addressing a documented research gap: while six million Medicare beneficiaries rely on home health agencies annually and people living...
- The National Institute on Aging awarded $431,996 to the Trustees of Indiana University, doing business as Indiana University Indianapolis, on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and deliver INSPIRE (Investigating Neurosciences, A Summer Program to Ignite Research and Education), an immersive summer research education program designed to attract and retain undergraduate science majors pursuing careers in Alzheimer's disease and related dementias research....
- The National Institute on Aging awarded Trustees of Indiana University (Indiana University Indianapolis) $624,837 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of the MR1/MAIT cell axis in Alzheimer's disease pathology and neuroinflammation. Work is performed in Indianapolis, Indiana through January 31, 2031. The research defines how MR1 molecules and mucosal-associated invariant T (MAIT) cells contribute to brain pathology in Alzheimer's disease...
- The National Institute on Aging awarded Purdue University $387,183 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop mass spectrometry-based proteomics strategies examining post-translational modifications related to protein aggregation and extracellular vesicle-mediated propagation in neurodegenerative disease, with emphasis on Alzheimer's disease. The recipient will establish a novel proteomics platform to profile N-terminal acetylation landscapes in primary...
- The National Institute on Aging awarded Trustees of Indiana University $433,593 on July 1, 2026, under the Aging Research program (CFDA 93.866) to integrate Centers for Medicare and Medicaid Services Medicare fee-for-service and Medicare Advantage inpatient data to improve hospital quality, outcomes, and disparities measurement. The project addresses a measurement gap created by Medicare Advantage enrollment growth to 55 percent of beneficiaries with Medicare Parts A and B coverage. Despite this...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
The National Institute on Aging, part of the Department of Health and Human Services, awarded $691,306 to Trustees of Indiana University (Indiana University Indianapolis) on August 15, 2026, under the Aging Research program (CFDA 93.866). The award funds research integrating real-world evidence from electronic medical records, cell line assays, and single-cell omics via deep reinforcement learning to identify repurposable drugs for Alzheimer's disease treatment. The project applies deep transfer learning models to identify high-risk cellular subpopulations associated with clinical and pathological features of Alzheimer's disease, then uses these subpopulations to select induced pluripotent stem cell (iPSC)-derived neural cell lines for mechanistic validation. Simultaneously, the research identifies and tests repurposable drug candidates from large real-world data cohorts of Alzheimer's disease patients against human iPSC-derived neural cells, combining molecular profiling, drug repurposing, and mechanistic studies to find targetable interventions. Performance occurs in Indianapolis, Indiana, with an ultimate completion date of May 31, 2031. The assistance type is a Project Grant, which is the standard mechanism for research funding under the National Institute on Aging's aging research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $691.3k | 8/12/26 |