Project Grant R21AG098408
- Federal Project Grant Award Summary Indiana University Indianapolis received a $1.58 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop and validate siRNA (small interfering RNA) therapeutic approaches targeting INPP5D for Alzheimer's disease treatment. The award, effective June 1, 2025, through March 31, 2030, funds research to identify and characterize INPP5D transcriptional variants in murine models and design self-delivering...
- Federal Grant Award Summary The National Institute on Aging (NIA) under its Aging Research program (CFDA 93.866) awarded Indiana University a $1.23 million Project Grant effective February 1, 2026, through January 31, 2031, to develop artificial intelligence (AI)-driven drug discovery pipelines targeting Alzheimer's disease and related dementias (AD/ADRD). The research will focus on three primary deliverables: (1) creation of an accelerated docking-based virtual screening pipeline...
- Federal Grant Award Summary The National Institute on Aging awarded a $317,000 Project Grant to Indiana University Indianapolis under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award supports research investigating chronic migraine as an early biomarker of Alzheimer's Disease (AD). The research project will examine the mechanistic relationship between migraine disorder and AD pathology progression, utilizing transgenic AD mouse models...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis $624,837 under the Aging Research program (CFDA 93.866) on February 15, 2026, to support research investigating the MR1/MAIT (Mucosal-Associated Invariant T) cell axis in Alzheimer's disease (AD) pathology. The award period extends through January 31, 2031. The research project seeks to advance understanding of how the MR1/MAIT cell axis contributes to neuroinflammation in AD through a...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $1,161,558 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct preclinical research on niacin receptor (HCAR2) activation as a therapeutic strategy for tauopathies. Awarded May 15, 2025, with completion targeted for February 28, 2030, this research addresses a significant unmet medical need, as tauopathies—including frontotemporal lobar degeneration...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $607,706 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded March 1, 2026, with a completion date of January 31, 2031. This award funds a five-year research project investigating short-term practice effects (STPE) as biomarkers for subjective cognitive decline (SCD), a preclinical manifestation of Alzheimer's disease. The research will examine whether...
- Federal Grant Award Summary The National Institute on Aging, under the Aging Research program (CFDA 93.866), awarded a $1.63M project grant to J. David Gladstone Institutes on June 15, 2025, with completion targeted for March 31, 2030. The research will leverage advanced machine learning (ML) approaches—specifically the Variational Animal Motion Embedding (VAME) platform—to conduct comprehensive behavioral and cognitive phenotyping in humanized Alzheimer's Disease (AD) knock-in mouse models. The...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Advantage Therapeutics, Inc. a Project Grant of $1,249,957 (awarded September 20, 2025) under the Aging Research program (CFDA 93.866) to conduct preclinical and Investigational New Drug (IND)-enabling studies on a novel small-molecule disease-modifying therapeutic for Alzheimer's disease. The proposed treatment is designed to reduce brain inflammation and restore phagocytosis, thereby improving amyloid...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $509,413 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025, with completion targeted for May 31, 2030. The award funds research investigating epitranscriptomic regulation of microglia in Alzheimer's Disease (AD), specifically examining how adenosine methylation (m6A) modifications control microglial cell...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
Project Grant Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis a Project Grant totaling $435,875 under the Aging Research program (CFDA 93.866) on April 15, 2026, with completion targeted for March 31, 2028. The project focuses on advancing Alzheimer's disease (AD) research through development and validation of a humanized SERPINA3 (Serine Protease Inhibitor A3) mouse model. SERPINA3 has been identified as a key mediator of AD pathogenesis, with preliminary research demonstrating that deletion of all 14 murine SERPINA3 orthologs in amyloidogenic transgenic models resulted in a striking 50-60% reduction in amyloid plaque burden within the brain. The primary product of this award is a novel humanized SERPINA3 mouse model designed to facilitate in vivo testing of SERPINA3-targeted therapeutics for AD treatment. By engineering a preclinical model that incorporates human SERPINA3 function into the established disease context, this research will enable accelerated translational development and validation of potential disease-modifying therapies. The deliverables will advance understanding of SERPINA3's mechanistic role in AD pathogenesis and provide researchers with a critical preclinical tool to evaluate novel SERPINA3-targeted interventions, ultimately supporting the development of new treatment options for this prevalent neurodegenerative disorder.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 4/10/26 |