Project Grant R01AG097812
- The National Institute on Aging awarded Mayo Clinic a Cooperative Agreement totaling $4,496,369 on August 18, 2026, under the Aging Research program (CFDA 93.866) to establish and operate the Mayo Clinic Study of Aging (MCSA) as a multi-site platform for validating and deploying blood-based biomarkers to guide clinical care in cognitive aging. The MCSA will develop and test biomarkers to quantify multifactorial contributions to cognitive impairment, including Alzheimer's disease, cerebrovascular...
- The National Institute on Aging awarded Mayo Clinic $678,684 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate the neural mechanisms of respiratory dysfunction in older age. The research explores how impaired autophagy in phrenic motor neurons contributes to selective loss of higher-force motor units with advancing age, and whether restoring autophagy prevents this loss. The project employs loss-of-function and gain-of-function experiments using conditional...
- The National Institute on Aging awarded Hebrew Rehabilitation Center $318,000 on August 18, 2026, under the Aging Research program (CFDA 93.866) to conduct a pilot study of home-based dual-task gait assessment in older adults at risk of dementia. The project will recruit 60 ambulatory adults aged 65 and older—30 with mild cognitive impairment and 30 age- and sex-matched controls—to use a smartphone-based gait application for daily assessments in their homes over a two-week baseline period,...
- The National Institute on Aging awarded $427,625 to The Washington University on September 1, 2026, under the Aging Research program (CFDA 93.866) to probe cerebellar cortex computations in Alzheimer's disease. The work examines cerebellar nodulus and uvula function in two Alzheimer's disease mouse models—APP/PS1 and 3XTG-AD—at 3, 6, and 12 months of disease progression to assess how hallmarks of Alzheimer's disease contribute to cerebellar dysfunction. The project tests the hypothesis that...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $522,463 to Mayo Clinic Jacksonville on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate UFM1 as a modifier of tau pathology in Alzheimer's disease and related tauopathies. The research will determine whether changes in the ufmylation cascade represent a universal feature across the tauopathy spectrum, identify the substrates to which UFM1 is conjugated in brain under...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded Mayo Clinic $678,987 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the impact of menopause on blood pressure regulation during exercise. The research tests whether locomotor muscle afferent feedback and respiratory muscle work contribute to exaggerated blood pressure responses and impaired leg blood flow in post-menopausal women during submaximal exercise. The project has two specific aims: to determine if locomotor...
- Federal Grant Award Summary Mayo Clinic received a $3.38 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded September 15, 2025, with completion targeted for September 14, 2029. The grant supports research to advance women-specific care in Alzheimer's disease and other dementias through systematic analysis of electronic health records (EHRs). The project addresses a critical gap in precision medicine by examining women-specific health...
- The National Institute on Aging awarded Emory University $643,613 on April 1, 2026, under the Aging Research program (CFDA 93.866) to discover glycosylation-based disease processes and identify glyco-biomarkers and targets for improving Alzheimer's disease diagnosis, prognosis, and intervention. The recipient will perform innovative research using an integrated platform of intact glycopeptide-based quantitative glycoproteomics and systems biology to elucidate brain glycoproteome alterations in...
The National Institute on Aging awarded Mayo Clinic $729,906 on September 3, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological substrates of falls in cognitively unimpaired older adults. The research uses dual-task paradigms that simultaneously engage motor and cognitive brain systems to characterize subclinical gait impairment patterns among cognitively unimpaired individuals who experience falls. The study assesses how gait impairment relates to Alzheimer's disease neuropathologic change and cerebrovascular disease using plasma biomarkers (amyloid, tau, neurofilament light, and glial fibrillary acidic protein) and neuroimaging markers including measures of cerebrovascular disease, cortical and subcortical brain atrophy relevant to gait control, and white matter microstructural integrity. The recipient will also follow individuals prospectively to evaluate fall risk outcomes. Work is performed in Rochester, Minnesota. The period of performance runs from September 3, 2026, through May 31, 2031. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/3/26 | ||
| Not listed | $729.9k | 9/2/26 |