Project Grant R01AG097534
- The National Institute on Aging awarded the University of California Irvine $1.238 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate longitudinal relationships between Alzheimer's disease pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The project uses multimodal neuroimaging combining polysomnography, high-density electroencephalography, and high-resolution structural magnetic resonance imaging of...
- The National Institute on Aging (National Institutes of Health, Department of Health and Human Services) awarded The Regents of the University of California, San Francisco $711,678 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate a gene-environment deviation (GED) framework quantifying the mismatch between observed sleep patterns and genetically predicted sleep preferences in relation to Alzheimer's disease and Alzheimer's disease-related dementias...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The Regents of The University of Colorado on July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity and subsequently disrupts sleep architecture in Alzheimer's disease. The research examines whether beta-amyloid accelerates death of hypocretin neurons...
- The National Institute on Aging awarded the University of California, San Diego $182,173 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how noradrenergic modulation during non-rapid eye movement sleep relates to memory consolidation and to test whether precise timing of cortical slow oscillations, thalamic spindles, and hippocampal sharp wave-ripples orchestrates memory transfer from hippocampus to cortical long-term memory. The research aims to understand how...
- The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
- The National Institute on Aging awarded Northwestern University $1,483,965 on March 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the proteomic signature of sleep and its implications for Alzheimer's disease. The project aims to investigate polysomnographic sleep biomarkers, proteomic blood biomarkers, and neurocognition in a large longitudinal sample of adults; disentangle the relationship between sleep, neurocognitive function, and circulating proteins using an...
- The National Institute on Aging awarded $775,637 to Icahn School of Medicine at Mount Sinai on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and evaluate the Soft Electronic Neurophysiological Assessment Patch Sensor (SENAPS), a compact, reusable, dry-electrode forehead EEG/EOG system for unsupervised multi-night sleep assessment in older adults. The project will develop an integrated SENAPS system consisting of a reusable forehead patch and cellular charging...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $697,394 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop and validate detailed quantification methods for 24-hour sleep and activity profiles from accelerometer data and to examine how modifiable activity behaviors affect Alzheimer's disease and related dementias outcomes. The project will establish approaches for robust, participant-level quantification of the full...
- The National Institute on Aging awarded The Washington University $578,856 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how sleep reinforces homeostatic set-points in neural activity and mitigates neurodegenerative disease. The award funds research applying novel computational tools to continuous multi-site recordings of neural activity in P301S mice, a tauopathy model, to test whether sleep enhancement can reinforce criticality—an optimal computational...
- The National Institute on Aging awarded the University of Pennsylvania $1,288,666 on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate sleep slow-wave activity as a risk factor for Alzheimer's disease in Black older adults. The research characterizes electroencephalogram power dynamics of slow-wave activity in 200 Black adults aged 55–80 through ambulatory overnight sleep monitoring with polysomnography and blood assessment panels measuring biomarkers of chronic...
The National Institute on Aging awarded Yale University $839,400 under the Aging Research program (CFDA 93.866) on September 1, 2026, to validate novel algorithms for assessing sleep deficiency in persons with Alzheimer's disease and related dementias. The project addresses the urgent need for feasible, accurate assessment methods for sleep deficiency in ADRD populations, where over half of patients experience sleep abnormalities that accelerate cognitive and functional decline. Existing gold-standard methods—polysomnography and dim light melatonin assays—are burdensome and often inaccurate when applied to this population. The research will examine 120 persons with ADRD across a nine-day protocol at baseline and follow-up to develop algorithms combining wearable multi-sensor headband data (electroencephalography, movement, and heart rate) with high-resolution actigraphy. The resulting algorithms will be publicly available and validated specifically for persons with ADRD and sleep disturbances, addressing limitations of proprietary algorithms developed using data from young, healthy adults without sleep disorders. The award carries a period of performance from September 1, 2026, through May 31, 2031, with place of performance in Connecticut. This is a Project Grant, the standard assistance type for NIH research funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $839.4k | 8/28/26 |