Project Grant R01AG097529
- Federal Grant Award Summary The University of Arizona received a $638,682 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective August 1, 2025, through May 31, 2030. This award supports scientific research investigating the intersection of transactive response DNA binding protein of 43 kilodaltons (TDP-43) liquid-liquid phase separation (LLPS) and mitochondrial dysfunction in neurodegeneration. The research addresses a critical gap...
- Federal Grant Award Summary The National Institute on Aging awarded University of California, Irvine a Project Grant totaling $1,546,062 under the Aging Research program (CFDA 93.866), effective June 1, 2025, through March 31, 2030. This award funds a multi-institutional research initiative investigating the molecular mechanisms of misfolded protein accumulation in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD), with emphasis on aberrant RNA splicing and tau pathology....
- Federal Grant Award Summary The University of Arizona received a $3.03 million Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded on September 30, 2025, with a completion date of September 29, 2029. Led by Principal Investigator Dr. Grilli, this research initiative will develop and validate novel semantic memory assessment tasks designed to detect early Alzheimer's disease (AD) pathology in cognitively unimpaired older adults and those with mild...
- Federal Project Grant Award Summary Ohio University has received a $567,256 Project Grant from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2029. This award supports biomedical research aimed at elucidating the mechanisms of activity-dependent tau protein release from neurons, with particular focus on understanding how neuronal hyperexcitability contributes to Alzheimer's disease pathogenesis and tau...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Arizona a Project Grant of $310,083 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. This award supports biomedical research investigating the role of TMEM106B (Transmembrane Protein 106B) and mitochondrial dysfunction in frontotemporal lobar degeneration (FTLD) and other dementias. The research focuses on clarifying the mechanisms by which genetic...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $456,500 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period February 1, 2026, through January 31, 2028. This award funds research investigating the role of heparan sulfate proteoglycans (HSPGs) in tau protein uptake, a critical mechanism in Alzheimer's disease progression. The project will identify the specific heparan sulfate size and sulfation...
- Federal Grant Award Summary Arizona State University received a $2,465,320 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with a completion date of September 14, 2029. The research project develops and validates a novel performance-based screening tool called the "Bean Game" to identify Alzheimer's disease (AD) risk in Hispanic/Latino older adults. The project addresses significant healthcare...
- Federal Grant Award Summary The University of Florida Division of Sponsored Research received a $419,375 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2026. The award supports research investigating the pathological implications of tau-ribonucleic acid (RNA) interactions in tauopathies, particularly Alzheimer's disease (AD). The project aims to identify and characterize RNA motifs that bind...
- Federal Grant Award Summary The Leland Stanford Junior University received a $2.29 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 1, 2025, with completion targeted for April 30, 2030. This research initiative investigates shared mechanisms of tau toxicity across multiple neurodegenerative diseases, with particular focus on understanding the mechanistic connection between tau protein abnormality and mitochondrial...
- Federal Project Grant Award Summary The University of California, San Francisco received a $805,573 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 15, 2025, with completion targeted for June 30, 2030. This award supports biomedical research investigating the impact of N6-methyladenosine (M6A) RNA modifications in Alzheimer's disease and related tauopathies. The research will characterize M6A-RNA dysregulation in post-mortem brain...
Arizona State University received a $675,329 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective May 1, 2026, through February 28, 2031. The award funds continued research and development of an innovative Alzheimer's disease and related dementias (ADRD) model utilizing adeno-associated virus (AAV) gene delivery of aggregation-prone tau protein into aged macaque monkeys. Building on prior findings, this research will characterize cellular pathology, biomarker progression, and neuroinflammatory responses across extended time points. The deliverables include comprehensive characterization of tau biochemical progression from normal tau to neurofibrillary tangle formation, identification of neuronal cell loss patterns and therapeutic windows, assessment of microglial and astroglial responses, and evaluation of cerebrospinal fluid and blood biomarkers including tau isoforms, neurofilament light chain, and inflammatory markers that parallel human AD pathology. The research will generate detailed pathological, biochemical, and neuroimaging data documenting tau propagation across the entorhinal cortex connectome in aged subjects, thereby advancing understanding of age-related ADRD mechanisms and supporting the development of therapeutic interventions. Arizona State University's Office of Research and Sponsored Projects Administration will administer the research conducted at its Tempe, Arizona facility, with institutional oversight provided through the Arizona Board of Regents.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $675.3k | 4/17/26 |