Federal Project Grant Award Summary

Case Western Reserve University received a $1,256,627 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through January 31, 2031. The ADAPTT (Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets) initiative will deliver comprehensive genetic analysis services and research outputs aimed at identifying functional genes and genetic variations underlying Alzheimer's disease-associated loci. The project will integrate and analyze genomic data from the Alzheimer's Disease Sequencing Project (ADSP) and the Alzheimer's Disease Genetics Consortium (ADGC), consolidating previously separate single nucleotide variant (SNV), insertion-deletion (INDEL), and structural variant (SV) datasets while incorporating in silico analyses and in vitro molecular genetic functional data.

The research deliverables will focus on narrowing the gap between genome-wide association study (GWAS)-identified loci and viable therapeutic targets by determining the most likely functional genes and variations at each locus. This work directly addresses the critical need for genetically-driven therapeutic development in Alzheimer's disease treatment, where current approved therapeutics provide only modest benefits. The project will be executed through three parallel specific aims, with research activities conducted at the Cleveland, Ohio location under Case Western Reserve University's Office of Research Administration in affiliation with University Hospitals of Cleveland.