Project Grant R01AG100231
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $593,146 under the Aging Research program (CFDA 93.866) effective January 1, 2026, through November 30, 2030. This research project will investigate mechanisms of activity-dependent transcription and DNA repair in neuronal longevity, with the overarching goal of defining new mechanisms that promote neuronal DNA repair and transcriptional fidelity across the lifespan. The...
- Federal Grant Award Summary Marquette University received a Project Grant award of $424,875 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2026, with completion targeted for May 31, 2028. The award supports neuroscience research investigating how ovarian hormones and age influence the prefrontal cortex's encoding of episodic fear memories across the lifespan. The project employs in vivo miniscope calcium imaging technology to track...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant of $556,121 under the Aging Research program (CFDA 93.866) to conduct research on transgenerational epigenetic adaptation of longevity changes in response to repeated environmental stresses. The award, effective January 15, 2026, through December 31, 2030, supports a five-year research initiative based at the university's St. Louis, Missouri facility. The project aims to advance...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $1,366,056 under the Aging Research program (CFDA 93.866) to develop an innovative fiber implant system for long-term, deep-brain imaging and manipulation in mouse models of Alzheimer disease. Initiated January 1, 2026, and extending through December 31, 2030, this project addresses critical limitations in existing neuroimaging technologies by creating a minimally invasive, biocompatible implant...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $162,000 Project Grant under the Aging Research program (CFDA 93.866) effective March 1, 2026, through February 28, 2029. This project focuses on identifying and characterizing novel therapy targets in TDP-43 (TAR DNA-binding protein 43) proteinopathies, a class of age-related neurodegenerative diseases affecting millions of patients worldwide. The research addresses a critical gap in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Southern California $4,055,366 under the Aging Research program (CFDA 93.866) to conduct a four-year research project examining the impact of circulating endocrine disrupting toxicants on cognition, brain activity, and Alzheimer's disease (AD) biomarkers across the menopausal transition. The project, which commenced on September 15, 2025, and concludes August 31, 2029, addresses a critical gap...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $149,190 Project Grant effective August 6, 2026, under the Aging Research program (CFDA 93.866) to conduct biomedical research on the mechanisms of NBR2, a long non-coding ribonucleic acid (RNA), in human ovarian aging. The research addresses a critical gap in understanding ovarian aging, which the proposal identifies as the first organ system to age in the human body and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $150,114 under the Aging Research program (CFDA 93.866) on March 18, 2026, with a completion date of November 30, 2027. This Project Grant supports research investigating the role of brain-engrafted monocyte-derived macrophages (MDMs) in Alzheimer's disease (AD) pathogenesis. The research addresses a critical gap in understanding brain macrophage heterogeneity and the immune mechanisms...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Washington a $651,175 Project Grant on February 1, 2026, under the Aging Research program (CFDA 93.866) to support longitudinal research examining the developmental pathways linking female pubertal timing to long-term health outcomes. The project delivers a second follow-up (FU2) visit for female participants in the landmark National Institute of Child Health and Human Development (NICHD) Study of Early...
- Federal Project Grant Award Summary The University of Florida's Division of Sponsored Research received a $2.33 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. The award funds research evaluating neuroimmune mechanisms and therapeutic targeting potential of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor in menopausal and Alzheimer's disease-affected brains....
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded The Washington University a Project Grant of $326,550 effective June 15, 2026, through March 31, 2031. This award funds biomedical research directed toward understanding the neural circuit mechanisms underlying age-related changes in female social behavior, specifically addressing menopause-related depression, social withdrawal, and loss of sexual motivation. The research will examine how hormonal decline disrupts a hormone-sensitive neural circuit projection from cholecystokinin A receptor (CCKAR)-expressing neurons in the ventromedial hypothalamus to the anteroventral periventricular nucleus (AVPV), with particular focus on determining structural and functional circuit changes, reversibility through hormone supplementation, and potential circuit-based therapeutic interventions. The research outputs will include scientific findings on the neurobiological mechanisms linking reproductive aging to behavioral impairments, identified through three specific aims: quantifying structural atrophy of the targeted neural projection; examining functional circuit activity changes associated with hormonal decline; and evaluating optogenetic pathway activation for behavioral restoration. These deliverables will contribute to the NIA's mission of supporting biomedical research directed toward understanding aging processes and age-related diseases, with potential application to developing novel circuit-based therapies to support mental health and social functioning in aging populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $326.6k | 6/8/26 |