Project Grant R01AG094597
- The National Institute on Aging awarded Yale University $461,311 under the Aging Research program (CFDA 93.866) on May 1, 2026, to investigate vascular smooth muscle cell aging and epigenetic reprogramming as a pathway to reducing cardiovascular disease risk. The research examines how smooth muscle cells in arterial walls undergo epigenetic alterations—particularly DNA methylation changes—that drive vascular stiffening and atherosclerosis in aging. Yale's team has developed smooth muscle...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $2,409,629 in Project Grant funding on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of neuronal ryanodine receptor type 2 (RYR2) in cognitive impairment associated with heart failure. The research aims to uncover the mechanisms by which cognitive impairment develops in both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced...
- The National Institute on Aging awarded the University of Pennsylvania $2,809,832 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic mechanisms driving cellular aging and age-associated disease. The award funds four integrated research projects examining chromatin homeostasis ("chromostasis") and senescence-associated secretory phenotype (SASP) in aging tissues. The research hypothesizes that age-related epigenetic changes result from...
- The National Institute on Aging awarded Mayo Clinic $660,157 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of BRD4 in enhancing preservation quality of donor hearts from older individuals through three-dimensional chromosomal restructuring. The project addresses a critical shortage in the donor heart supply for transplantation. Older donor hearts are often rejected due to elevated risk of primary graft dysfunction; in 2024, only 303 hearts from...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $154,960 to the University of Kansas Medical Center Research Institute, Inc. on February 26, 2026, under the Aging Research program (CFDA 93.866). The recipient will conduct research combining cellular and clinical measures to examine bioenergetic contributions to tau phosphorylation in aging and Alzheimer's disease. The work leverages existing clinical data from the KU...
- The National Institute on Aging awarded Iowa State University of Science and Technology $523,313 on June 1, 2026, under the Aging Research program (CFDA 93.866) for a Project Grant addressing non-autonomous regulation of cardiac aging through investigation of kidney-derived plasmalogen ether phospholipids. The research interrogates the role of plasmalogens—a class of ether phospholipids—in inter-tissue communication and cardiac aging. Plasmalogen deficiency has been linked to impaired...
- The National Institute on Aging awarded the University of Missouri System $429,394 on December 15, 2025, under the Aging Research program (CFDA 93.866) to investigate LARP6 as a druggable target for aging-associated heart failure with preserved ejection fraction (HFPEF) in co-morbid conditions including obesity and hypertension. The research examines how LARP6, an RNA binding protein implicated in pathologic cardiac fibrosis, regulates collagen messenger RNA stability and translation....
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $472,658 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop live-cell imaging tools that monitor biological age in real time based on age-associated DNA methylation changes. The project will engineer two classes of genetically encoded fluorescent sensors: a "ticking" global methylation epigenetic clock that continuously visualizes intranuclear 5-methylcytosine patterns,...
- The National Institute on Aging awarded the University of Texas Health Science Center at Houston $429,000 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate endothelial senescence intervention in limb muscle ischemia using exercise mimetics. The research will measure the effect of exercise mimesis on preventing or reversing muscle decline associated with peripheral arterial disease in aging populations. The project employs unique transgenic mouse lines, including...
The National Institute on Aging awarded the University of Tennessee Health Science Center $624,442 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic regulation of heart function in health and aging. The research examines the role of KDM6A, a histone demethylase, in normal heart function and aging-related heart injury. The project pursues two specific aims using state-of-the-art molecular approaches to identify novel mechanisms underlying aging-associated heart failure and remodeling, with the objective of revealing preventive and therapeutic strategies for age-related cardiac decline. Work is performed in Memphis, Tennessee, with a period of performance extending from August 1, 2026, through April 30, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $624.4k | 7/22/26 |