Project Grant R01AG093890
- Federal Project Grant Award Summary Emory University received a $494,109 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 15, 2026, with completion targeted for January 31, 2031. The award funds a randomized, double-blind, placebo-controlled clinical trial investigating citicoline supplementation as a therapeutic intervention for residual sleepiness and inflammation in older adults with obstructive sleep apnea...
- Federal Project Grant Award Summary Proactive Life Inc. received a $499,963 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 20, 2025, through September 19, 2026. The awardee will develop and validate SleepSpace AI, a fully automated Internet of Things (IoT)-enabled cognitive behavioral therapy for insomnia (CBTI) system designed to improve sleep quality and cognition in older adults. The technology leverages...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a five-year Project Grant totaling $619,099 to the University of California, Irvine, effective February 1, 2026 through January 31, 2031, under the Aging Research program (CFDA 93.866). The research initiative investigates longitudinal relationships between Alzheimer's Disease (AD) pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The project will employ an...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $578,856 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of January 31, 2031. This award supports scientific research investigating the relationship between sleep and neurodegenerative disease, with the objective of identifying mechanisms through which sleep reinforces homeostatic set-points in neural activity and determining...
- Federal Project Grant Award Summary Emory University received a $147,656 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of March 11, 2025 and project completion date of September 29, 2025. The grant supports the development of the first human locus coeruleus (LC) organoid model to advance understanding of Alzheimer's disease (AD) pathology. The research addresses a critical gap in AD knowledge by utilizing...
- Federal Project Grant Award Summary Emory University received a $528,876 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2025 through March 31, 2030. This award supports the development and application of novel analytical tools to investigate cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias (AD/ADRD). The research extends current...
- Federal Grant Award Summary Emory University received a $657,222 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded February 15, 2026, with a completion date of January 31, 2031. The grant supports research investigating the pathological mechanisms of amyloid-beta (Aβ) protein interactions in Alzheimer's disease (AD). The project will deliver scientific findings through three primary research objectives: determining the molar abundance...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $868,901 on March 1, 2026, under the Aging Research program (CFDA 93.866) to conduct the Sleep and Circadian Rhythm Biomarkers of Postoperative Neurocognitive Recovery (SLEEP-POD2) study through January 31, 2031. This multisite longitudinal research initiative will enroll 400 older non-cardiac surgery patients (age 65+) from Boston and Baltimore to investigate the relationship between...
- Federal Grant Award Summary The National Institute on Aging awarded a $464,750 Project Grant to Icahn School of Medicine at Mount Sinai on September 5, 2025, under the Aging Research program (CFDA 93.866). This research project will investigate the differential effects of chronic sleep disruption and intermittent hypoxia in obstructive sleep apnea (OSA) on tau pathology and neuronal spread, with the objective of clarifying how OSA contributes to Alzheimer's disease risk. The primary...
- Federal Project Grant Award Summary Washington State University received a $420,750 Project Grant award dated August 5, 2025, from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct research on the reciprocal interactions between sleep disruption, cognitive decline, protein aggregation, and transcriptional processing in an Alzheimer's disease model. The research will extend through July 31, 2027, and utilizes an APP/PS1 transgenic rat model to investigate...
Emory University received a $627,646 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 15, 2026, with a completion date of January 31, 2031. The grant funds a randomized controlled trial examining the efficacy of REPAIR Sleep, a five-week cognitive behavioral therapy for insomnia (CBT-I) intervention delivered via videoconferencing to dyads consisting of persons living with dementia and their caregivers. The research addresses the significant health burden of sleep disturbances affecting up to 71% of individuals with Alzheimer's disease and related dementias, which negatively impacts both patients and their caregivers through nocturnal wakefulness, fragmented sleep, and increased caregiver burden. The primary deliverables under this grant include conducting a rigorous randomized controlled trial with 120 patient-caregiver dyads to evaluate the immediate and six-month efficacy of the REPAIR Sleep intervention compared to an attention control intervention titled Healthy Living. The study is grounded in established theoretical frameworks—the Modified Spielman 3P Model of Insomnia and the Theory of Dyadic Illness Management—and builds upon a successful pilot demonstration of feasibility and acceptability. The research will generate evidence on whether partnered CBT-I interventions, delivered remotely and engaging both care recipients and caregivers jointly in treatment sessions, represent an effective alternative to medication-based approaches for addressing sleep disturbances in dementia populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $627.6k | 2/3/26 |