Project Grant R21AG088736
- This federal Project Grant award of $125,000.00, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the relationship between sleep loss and neurodegeneration. The grantee, The Washington University, will use the funding to examine how sleep deprivation can epigenetically alter microglial responses to tau protein aggregates, which is a key pathological feature of Alzheimer's disease and other tauopathies. The research aims to identify...
- The National Institute on Aging (NIA) awarded a $785,348 project grant (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies in La Jolla, California. The project, titled "Chronic Sleep Disruption is a Stressor for Healthspan and Lifespan", will investigate the biological mechanisms by which chronic sleep disruption (CSD) may interact with the aging process to increase the risk of age-related diseases. The research aims to determine if long-term CSD affects the...
- This $612,005 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to characterize sleep slow-wave activity (SWA) and its relationship to chronic stress, accelerated aging, and Alzheimer's disease in a cohort of 200 Black older adults aged 55-80 in the United States. The award will support ambulatory overnight sleep monitoring, biomarker assessments, and cognitive testing to examine how chronic stress impacts SWA and its association with markers of...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a Project Grant in the amount of $4,035,962.00 to the Icahn School of Medicine at Mount Sinai (ISMMS) on September 15, 2025. The grant is titled "Examining Unique Markers and Risk Factors for AD/ADRD in Foreign- and Native-Born Older Chinese Americans: A Study of Social Determinants of Health, Sleep Patterns, Neuroimaging, and Plasma Biomarkers." The project aims to...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This $789,664 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project titled "Dissecting the Cellular and Spatial Tissue Clock of the Human Lung and Peripheral Blood" at the Icahn School of Medicine at Mount Sinai. The project aims to leverage single-cell RNA sequencing and spatial transcriptomics to characterize the effect of age on the cellular microenvironment of the human lung and peripheral blood. The research will...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is focused on assessing whether genetic risk variants for Alzheimer's disease (AD) have a pleiotropic effect on sleep. The primary objectives are to conduct in silico variant-to-gene mapping analysis to identify potential shared genetic factors underlying AD and sleep phenotypes, and to use CRISPR in zebrafish models to directly evaluate the impact of putative AD...
- This $782,473 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to improve understanding of the pathogenesis of sleep apnea using novel imaging techniques during sleep. The project aims to characterize the site and pattern of airway collapse as well as how upper airway anatomy mediates this collapse, which could provide new insights to guide optimal therapies, particularly for patients who cannot tolerate...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $684,924 to Northwestern University to conduct research on the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia. The project aims to systematically characterize central and peripheral measures of the NA system and assess their association with sleep quality and cognitive performance in older adults with insomnia, as well as...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $816,472 project grant to the Icahn School of Medicine at Mount Sinai (ISMMS). The grant, awarded on August 1, 2025 and set to conclude on May 31, 2029, aims to enhance cardiovascular risk prediction and treatment response in obstructive sleep apnea (OSA) patients using advanced AI-based transformer models and multi-modal sleep data. The project will...
This $464,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "DIFFERENTIATING CHRONIC SLEEP DISRUPTION FROM INTERMITTENT HYPOXIA IN OSA ON TAU PATHOLOGY AND SPREAD" at the Icahn School of Medicine at Mount Sinai. The project aims to investigate the separate effects of chronic sleep disruption and intermittent hypoxia associated with obstructive sleep apnea (OSA) on the spread of tau pathology, a crucial step in the development of Alzheimer's disease. The award period is from Sep 5, 2025 to Aug 31, 2027. This research seeks to provide insights into how OSA may impact the risk and progression of Alzheimer's disease by examining the impacts on tau protein accumulation and propagation in the brain.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $464.8k | 9/4/25 |