Project Grant R01AG093843
- Federal Grant Award Summary Massachusetts General Hospital received a $453,750 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. The award supports a comprehensive five-year research initiative investigating the role of circadian rhythm disruption and sleep disorders in perioperative neurocognitive disorders (PND)—cognitive impairments that...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $453,750 Project Grant to Massachusetts General Hospital (MGH) on February 15, 2026, under the Aging Research program (CFDA 93.866) to establish and conduct a longitudinal cohort study examining sleep, circadian rhythm disruptions, and cognitive outcomes in older Chinese immigrants aged 65 and above. The research will establish a cohort of 100 older Chinese immigrants—referred to as "zeroth...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a five-year Project Grant totaling $619,099 to the University of California, Irvine, effective February 1, 2026 through January 31, 2031, under the Aging Research program (CFDA 93.866). The research initiative investigates longitudinal relationships between Alzheimer's Disease (AD) pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The project will employ an...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $578,856 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of January 31, 2031. This award supports scientific research investigating the relationship between sleep and neurodegenerative disease, with the objective of identifying mechanisms through which sleep reinforces homeostatic set-points in neural activity and determining...
- Federal Grant Award Summary The National Institute on Aging awarded the Regents of the University of Michigan a $107,097 Project Grant effective September 16, 2025, through June 30, 2027, under the Aging Research program (CFDA 93.866). This research project investigates the relationship between sleep disturbances and age-related memory loss by examining how sleep deprivation alters the activity and connectivity of somatostatin-expressing inhibitory interneurons in the hippocampus. The research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $577,122 Project Grant on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a clinical research study examining electroencephalogram (EEG)-guided anesthesia protocols for reducing post-operative delirium (POD) in elderly surgical patients. The primary deliverable is a randomized controlled trial involving elderly patients undergoing general...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $453,750 Project Grant to Massachusetts General Hospital (MGH) effective September 1, 2025, through August 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports a translational research initiative investigating the mechanisms by which sleep and circadian rhythms influence postoperative recovery outcomes, with particular focus on total knee...
- Federal Grant Award Summary The National Institute on Aging awarded a $464,750 Project Grant to Icahn School of Medicine at Mount Sinai on September 5, 2025, under the Aging Research program (CFDA 93.866). This research project will investigate the differential effects of chronic sleep disruption and intermittent hypoxia in obstructive sleep apnea (OSA) on tau pathology and neuronal spread, with the objective of clarifying how OSA contributes to Alzheimer's disease risk. The primary...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $3.24 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on September 23, 2025, with a completion date of June 30, 2027. The project investigates the mechanistic pathways linking irregular sleep schedules to cognitive impairment and neurodegenerative disease risk. The research delivers empirical findings on...
- Federal Project Grant Award Summary The National Institute on Aging awarded The Washington University $125,000.00 under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of June 30, 2027. This project grant funds scientific research investigating the mechanistic relationship between sleep loss and neurodegeneration, with a specific focus on how epigenetic modifications in microglial responses may influence the progression of tauopathies such as Alzheimer's...
The National Institute on Aging (NIA) awarded Massachusetts General Hospital $868,901 on March 1, 2026, under the Aging Research program (CFDA 93.866) to conduct the Sleep and Circadian Rhythm Biomarkers of Postoperative Neurocognitive Recovery (SLEEP-POD2) study through January 31, 2031. This multisite longitudinal research initiative will enroll 400 older non-cardiac surgery patients (age 65+) from Boston and Baltimore to investigate the relationship between perioperative sleep and circadian rhythm disruption, postoperative delirium (POD) vulnerability, and long-term cognitive decline associated with Alzheimer's disease and related dementias (ADRD). The research will comprehensively assess sleep and circadian measures using ambulatory actigraphy, electronic sleep diaries, and EEG headbands, while evaluating preclinical Alzheimer's disease pathology through plasma biomarkers and cognitive function using the National Institutes of Health Toolbox Cognition Battery at multiple longitudinal timepoints. This project builds upon preliminary findings from the SLEEP-POD pilot study and leverages Massachusetts General Hospital's established perioperative sleep research infrastructure and geriatric research expertise to rigorously test whether sleep and circadian rhythm disruption serve as modifiable risk factors for POD and subsequent cognitive decline. By identifying sleep health as a key intervention target in the postoperative period, this research aligns with the NIA's mission to support investigations addressing age-related diseases and advancing prevention and treatment strategies for vulnerable older adults undergoing surgery.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $868.9k | 2/18/26 |