Project Grant R01AG093805
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $2.86 million Project Grant under the Aging Research program (CFDA 93.866) to Henry Ford Health + Michigan State University Health Sciences, with performance in Michigan from August 15, 2025, through July 31, 2029. This research initiative addresses the mechanisms by which cadmium exposure—a toxic heavy metal to which up to 20% of Americans have elevated exposure levels—contributes to Alzheimer's disease (AD) pathology...
- Federal Project Grant Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.9 million Project Grant (CFDA 93.866, Aging Research program) effective August 1, 2025, through July 31, 2029, to develop a Multi-Organ AI-derived Endophenotype (MAE) platform for personalized Alzheimer's disease and related dementia (ADRD) susceptibility assessment. The research initiative integrates large-scale multi-omics data, multi-organ biomedical datasets, advanced...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $852,273 through the Aging Research program (CFDA 93.866) to conduct a comprehensive genetic mapping study of RNA modifications in the aging human brain and their association with Alzheimer's disease (AD). This project grant, initiated September 1, 2025, with completion targeted for May 31, 2030, will deliver a multi-faceted research effort examining how genetic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a $2,957,210 Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award funds comprehensive biomedical research investigating the role of CD44 astrocytes in Alzheimer's disease (AD) pathophysiology. The research project will elucidate the functional mechanisms by which CD44 upregulation...
- This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant totaling $475,377 on September 5, 2025, under the Aging Research program (CFDA 93.866) through its Health Sciences Division. The grant funds a two-year research initiative (completion date: August 31, 2027) to investigate the functional significance of FOXO3 (Forkhead Box O-3) in microglial cells and its role in Alzheimer's Disease (AD)...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $452,375 under the Aging Research program (CFDA 93.866) for a project grant spanning January 1, 2026, through December 31, 2027. This research project investigates the functional role and mechanistic basis of semaphorin 3A (SEMA3A) in microglial activation and Alzheimer's disease (AD) pathobiology. The research leverages human induced pluripotent stem cell...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant of $6,290,600 under the Aging Research program (CFDA 93.866), effective August 1, 2025, through July 31, 2029. This research initiative employs integrated multi-omics approaches combined with biochemical and functional methodologies to investigate how the ubiquitin-proteasome system (UPS), specifically proteasome complexes, are affected across...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $244,023 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) effective August 1, 2025, through July 31, 2028, under the Aging Research program (CFDA 93.866). This award supports research investigating the social mechanisms underlying sex differences in Alzheimer's disease (AD), with particular focus on how contextual determinants and societal barriers influence...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Regents of the University of Minnesota $645,743 under the Aging Research program (CFDA 93.866) to conduct a longitudinal epidemiological study examining the relationship between childhood socioeconomic status (SES) and lead (Pb) exposure on dementia risk in later life. The project, spanning February 1, 2026 through December 31, 2030, creates a novel research data source by linking approximately 15,792...
The National Institute on Aging awarded Columbia University's Health Sciences Division a $8.09M Project Grant (CFDA 93.866 - Aging Research) effective February 1, 2026, through January 31, 2030, to investigate the association between metal exposures and Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) risk in diverse U.S. populations. The research leverages two existing NIH-funded cohort studies—the Atherosclerosis Risk in Communities (ARIC) and the Multi-Ethnic Study of Atherosclerosis (MESA)—to comprehensively evaluate how metal exposures contribute to mild cognitive impairment (MCI) and AD/ADRD through multiple pathophysiological mechanisms. Under this award, Columbia will develop and implement a metallome profiling protocol to quantify metal exposure and internal dose across priority metals including lead, cadmium, copper, mercury, manganese, and zinc, using samples from urine, blood, serum, and brain-derived extracellular vesicles collected at repeated study visits. The research integrates these metallome profiles with multi-omics data—including whole genome sequencing, epigenomic/methylomic analysis, transcriptomic, proteomic, and metabolomic measurements—to identify prospective associations between metal exposures and cognitive decline while determining the biological pathways through which metals influence AD/ADRD risk, particularly in interaction with genetic factors such as the APOE4 allele.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $8.1m | 1/30/26 |