This $125,896 Project Grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a research project led by The Washington University in St. Louis. The project aims to utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and Alzheimer's disease (AD) human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience pathways across genetic, epigenomic,...
This $143,135 Project Grant award from the National Institutes of Health's National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of short tandem repeat (STR) genetic variations in the pathogenesis and progression of Alzheimer's disease. The principal investigator, who is a physician-scientist with expertise in human genetics and Alzheimer's clinical care, will pursue three key objectives: 1) Assess whether STR expansions correlate with age of...
This $575,667 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Mississippi Medical Center (UMMC) on August 1, 2024. The grant supports research to characterize the role of Activated Protein C (APC) signaling in the pathogenesis of Alzheimer's disease (AD) and to elucidate the capability of APC derivatives to improve neurocognitive function against AD. Key aspects include examining how APC depletion impacts metabolic and redox...
This $460,625 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the role of cellular senescence pathways in the pathogenesis of Alzheimer's disease (AD). The award will fund the University of Massachusetts Medical School (UMass Medical) to utilize human induced pluripotent stem cell (iPSC)-based models to independently dissect the impact of the p53/p21 and p16 senescence pathways on AD-related cellular pathologies in differentiated...
This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, aims to establish targeting the protein CAPON as a promising therapeutic strategy for Alzheimer's disease (AD). The $1,980,378 grant supports research to screen a chemical library for small molecule inhibitors of the CAPON-tau and CAPON-nNOS interactions, which are implicated in AD pathogenesis. The 3-year project will validate the therapeutic potential of optimized lead compounds...
This federal Project Grant award of $528,876.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will support a 5-year research study to investigate the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias (AD/ADRD). The key objectives are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) for transcriptome-wide genes and proteome-wide proteins across multiple brain...
This federal Project Grant award under the National Institute on Aging's Aging Research program (CFDA 93.866) provides $913,225 to St. Jude Children's Research Hospital Inc. to conduct a comprehensive research project on Alzheimer's disease (AD) and related dementias (ADRD). The project aims to systematically characterize the role of U1 small nuclear ribonucleoprotein (U1 SNRNP) proteinopathy and its impact on RNA splicing dysfunction in the pathogenesis of AD/ADRD. The research will leverage...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,559,999 to the Regents of the University of Michigan to conduct a comprehensive study on the APOE gene and the noncoding RNA AANCR to advance Alzheimer's disease treatment. The research aims to elucidate how AANCR regulates APOE transcription and how AANCR is modulated to maintain cell-type specific and stress-induced APOE expression. The project will also assess the effects of APOE...
The National Institute on Aging (NIA) awarded a $1,055,595 Project Grant (CFDA 93.866 Aging Research) to Colorado State University (CSU) to conduct research targeting age-related endosome dysfunction in Alzheimer's disease (AD). The key objectives are to 1) determine how increasing endosome formation decreases tau protein in neurons, and 2) define how enhancing endosome formation impacts cognition and AD pathology in mouse models. This research aims to establish decreased endosome formation as a...
This $459,076 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the early transcriptional and pathological changes in vulnerable brain regions during the prodromal stage of Alzheimer's disease (AD). The project will leverage single-nucleus RNA sequencing and targeted mass spectrometry analysis of postmortem brain samples from individuals with early-stage AD pathology to profile gene expression changes and identify...