Project Grant RF1AG084635

Award Date 8/15/24
Completion Date 7/31/27
Dollars Obligated $2M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
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  1. Screen a chemical library to identify small molecules that can bind to and inhibit the interactions of CAPON with the tau protein and nitric oxide synthase, which are implicated in AD pathogenesis.

  2. Optimize the identified small molecule hits through structural refinement and validation using in vitro assays.

  3. Evaluate the therapeutic potential of the optimized lead compounds in AD mouse models to assess their ability to block CAPON-mediated tau aggregation and neurodegeneration.

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