Project Grant R01AG093208
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $132,705.00 on June 15, 2025, to The Children's Hospital Corporation (Boston Children's Hospital) under the Aging Research program (CFDA 93.866). This award supports research addressing hematopoietic clonal dominance during aging—a condition in which driver mutations cause a limited number of hematopoietic stem and progenitor cell (HSPC) clones to disproportionately contribute to blood cell...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 1, 2025, with a completion date of July 31, 2027. The award supports basic immunological research investigating the cell-specific roles of CD153 and CD30 in regulating immune responses, with particular focus on age-related immune...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital a Project Grant totaling $167,940 on August 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease (AD). The research project, scheduled for completion by May 31, 2030, aims to elucidate how MEF2 transcription factors (MEF2A and MEF2C) promote neuronal survival and cognitive resilience in individuals...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $829,319 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 1, 2026, through November 30, 2030. The award supports basic biomedical research aimed at identifying collaborating factors that drive DDX41 mutant pathology in myelodysplastic syndromes (MDS)....
- Federal Project Grant Summary Award Details: St. Jude Children's Research Hospital Inc. received a $1.76 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 1, 2025, with a completion date of March 31, 2030. The grant funds research into proteogenomics of splicing proteinopathies in neurodegeneration, with collaborative sub-awards to Banner Health, University of Tennessee Health Science Center, and University of...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $445,130 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective January 1, 2026, through December 31, 2030. This research project focuses on elucidating the mechanisms by which MS4A (Membrane Spanning 4A) genes regulate neurodegeneration in Alzheimer's disease and related neurodegenerative disorders, including frontotemporal dementia, multiple...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,587,554 under the Aging Research program (CFDA 93.866), effective June 17, 2025, with a completion date of April 30, 2030. The project will deliver comprehensive research services and scientific outputs focused on understanding how mitochondrial DNA (mtDNA) compaction influences the accumulation of somatic mutations over an individual's lifetime, with implications...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pittsburgh a $3.1 million Project Grant under the Aging Research program (CFDA 93.866) for the period September 1, 2025, through August 31, 2029. This research project investigates the mechanistic link between persistent DNA damage and the immune response pathway in aging and DNA repair-deficient conditions. The award supports biomedical research directed toward understanding how the NLRP12 (NOD-like...
- Federal Grant Award Summary The National Institute on Aging awarded a $1,588,818 Project Grant to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (operating as Cleveland Clinic Lou Ruvo Center) for the period June 1, 2025, through February 28, 2030, under the Aging Research program (CFDA 93.866). The award funds development of a Multimodal, Multiscale and Multistage Systems Biology (M3SB) infrastructure designed to advance precision medicine in Alzheimer's...
- Federal Grant Award Summary The Washington University's Office of Sponsored Research Services received a $388,749 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 6, 2025, through July 31, 2030. This award funds research to understand the impact of clonal hematopoiesis on aging human bone marrow in disease-free adults. The research project investigates how somatic mutations that...
Cincinnati Children's Hospital Medical Center received a $645,245 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period April 1, 2026 through March 31, 2031. The grant supports research investigating the effect of DDX41 mutations on hematopoiesis during aging, with particular focus on understanding myelodysplastic syndromes (MDS)—bone marrow failure disorders caused by clonal expansion of hematopoietic stem cells (HSCs). The research deliverables include scientific investigations examining how biallelic DDX41 mutations, particularly the common truncating/R525H combination observed in MDS patients, affect HSC proliferation, survival, and clonal expansion. The project will utilize patient sequencing studies and published mouse models to elucidate mechanisms by which DDX41-mutated HSCs become selectively favored despite causing profound defects in hematopoietic progenitor function. Findings from this five-year project are expected to advance understanding of how inherited and acquired DDX41 mutations contribute to MDS development, potentially informing diagnostic and therapeutic approaches for this aging-related blood disorder that currently accounts for approximately 4% of MDS cases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $5.2k | 4/3/26 | ||
| Not listed | $640.1k | 3/27/26 |