Project Grant DP5OD039424
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $101,771 to The Washington University to investigate the impact of clonal hematopoiesis on solid tumor development and response to radiation therapy. Specifically, the project aims to quantify the effect of TET2-mutant hematopoietic cells on lung tumor growth and treatment, as well as identify the spectrum of clonal hematopoiesis-mutant immune cells that infiltrate the tumor...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- This Project Grant award of $742,391 from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) supports research conducted by Tufts University School of Medicine to develop an in vivo model system that can recapitulate the development and evolution of clonal hematopoiesis (CH) during aging, tumorigenesis, and cancer treatment. CH is a premalignant condition associated with increased risk of hematologic malignancies, particularly in cancer patients undergoing...
- The federal Project Grant award of $202,982.00 was provided by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to Cold Spring Harbor Laboratory to conduct research aimed at "Understanding and Targeting Senescence in Clonal Hematopoiesis". The research project seeks to identify inflammatory mediators and cell-autonomous pathways in clonal hematopoiesis (CH) that may serve as potential therapeutic targets to restore oligoclonal hematopoiesis and address the adverse...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
- This $147,486.00 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of high-fat diet in hematopoiesis (blood cell formation) and clonal hematopoiesis, a condition associated with increased risk of myeloid diseases like myelodysplastic syndrome and acute myeloid leukemia. The award was made to the Regents of the University of Michigan, Ann Arbor for a project period running from Jul 9,...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,705 Project Grant under the Aging Research program (CFDA 93.866) to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The award aims to conduct research on "Targeting Metabolic Vulnerabilities to Restore Balanced Hematopoiesis During Aging," with a project period from June 15, 2025 to May 31, 2027. The research will use single-cell...
- This federal Project Grant award for $802,301, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research by Weill Medical College of Cornell University to investigate the mechanisms that control the bone marrow "niche" environment and its role in expanding mutated blood stem cells that increase the risk of cardiovascular disease and cancer. The research aims to identify signaling pathways that can be targeted to prevent...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $166,644 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of Columbia University in the City of New York on July 16, 2025. This 5-year grant will support research examining how aging and TET2 mutations affect the inflammatory response of human hematopoietic stem cells. The research aims to improve understanding of how these factors contribute to the development of blood disorders like...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $388,749 to The Washington University in Missouri to conduct research focused on understanding the impact of clonal hematopoiesis on the aging human bone marrow. The goal is to investigate how these somatic mutations that can drive leukemia exist and interact within the bone marrow niche in cancer-free adults, which may yield insights into how these pre-malignant states can progress to blood cancers. The project will run from August 6, 2025 to July 31, 2030, and builds on prior techniques developed for studying rare mutations in the hematologic system. This research aims to enhance understanding of how genomic changes arise and drive tumorigenesis, with the potential to identify new interventions for preventing malignant transformation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.7k | 8/6/25 |