The National Institute on Aging (NIA) awarded a $245,148 project grant under the Aging Research Federal Grant Program (CFDA 93.866) to Eyenexo LLC to develop an automated rodent behavior testing system for early Alzheimer's disease (AD) assessment. The project aims to leverage computer vision to non-invasively evaluate defensive behaviors in rodents, such as freezing and escape responses to looming stimuli, which have been associated with early neurodegeneration in AD. The goal is to create a...
This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
The National Institute on Aging (NIA) awarded a $955,432 Project Grant under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University to conduct research on the "Neural Mechanisms of Gait Disturbances as Individualized Digital Biomarker Trajectories in Preclinical Dementia." The project aims to leverage cutting-edge AI and computer vision tools to identify nuanced markers of cognitive decline mirrored in gait and hand movement patterns, which can serve as...
This $619,681 federal Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop a powerful toolkit called "Combo-Seq/Tag" that combines gene editing and protein tagging techniques. The goal is to efficiently perturb Alzheimer's disease (AD) risk genes and enable multi-omics readouts in human stem cell models. The project will also generate a mouse model compatible with the...
This Project Grant award, valued at $10,847,672 and funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research on the mechanisms underlying cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The primary awardee, J. David Gladstone Institutes, will conduct comprehensive studies using human postmortem brain samples, single-cell genomics, and mouse models to elucidate how microglia regulate the balance between vascular...
The National Institute on Aging (NIA) awarded a $661,016 Project Grant (CFDA 93.866 - Aging Research) to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" platform. This project aims to leverage innovative artificial intelligence (AI) techniques and distributed computing to analyze Alzheimer's disease (AD) biobanks from the U.S., India, Japan, and Europe, totaling over 100,000 MRI and PET scans. The key...
This $5,274,018 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The J. David Gladstone Institutes will study the susceptibility and resistance to the detrimental effects of the Apolipoprotein E4 (APOE4) genetic risk factor for Alzheimer's disease. The research aims to characterize neurophysiological, behavioral, and neuropathological differences between new APOE4 mouse lines...
The National Institute on Aging (NIA) awarded a $762,636 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to The Leland Stanford Junior University (Stanford University) to develop rigorous machine learning (ML) methods and pair them with causal inference to discover causal genetic variants associated with Alzheimer's disease (AD). The project aims to significantly improve the understanding of the multiplex nature of AD and provide a credible set of well-defined, novel...
The National Institute on Aging (NIA) awarded a $4,276,054 Project Grant under the Aging Research program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) to conduct mathematical modeling and analysis of selective vulnerability in mouse tauopathy models relevant to Alzheimer's disease (AD). The project aims to quantitatively test hypotheses related to how protein aggregation, neural cell type composition, and network-based transmission of pathology contribute to...
The National Institute on Aging awarded a $1,198,947 Project Grant under the Aging Research program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) on September 30, 2023. The grant will fund research to investigate the neuroprotective effects of a blood-derived enzyme called GPLD1 on Alzheimer's disease pathology. Specifically, the project aims to: 1) examine the relationships between GPLD1, physical activity, immunovascular function, and cognition in older...