This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is funding a research project to investigate the neural mechanisms underlying cognitive contributions to walking as an early marker for risk of Alzheimer's disease and related dementias (ADRD). The total award amount is $2,030,488 and the project period runs from Sep 17, 2024 to May 31, 2029. The research aims to: 1) Investigate gait deficits during tasks requiring...
This Project Grant award of $3,211,894 from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) will fund research to investigate gait dysfunction as a preclinical marker for Alzheimer's disease and related dementias. The project will employ innovative gait phenotyping and multidisciplinary approaches to discover novel risk and protective mechanisms for gait issues in the context of dementia. Key objectives include identifying protective brain mechanisms linked to gait...
This Project Grant award of $835,056, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports the development of a multi-modal system of wearable biosensors and predictive analytics to enable continuous monitoring of mobility and cognitive function in older adults. The primary goals are to: Develop a system of flexible, breathable, and inconspicuous eutectogel sensor patches that can provide real-time monitoring of biophysical domains like gait, posture, heart rate,...
This $804,795 Project Grant was awarded on September 18, 2024 by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding supports a comprehensive research project investigating the neural mechanisms underlying the relationship between gait and cognitive function in individuals with subjective cognitive decline and a family history of Alzheimer's disease. The project aims to determine how declines in vestibular system function and...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $817,357 to the J. David Gladstone Institutes to develop advanced machine learning approaches for comprehensive behavioral and brain signal analysis in humanized Alzheimer's disease mouse models. The key products and services to be delivered include: Validating a machine learning platform called Variational Animal Motion Embedding (VAME) for high-resolution...
The National Institute on Aging (NIA) awarded a $619,681 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop innovative tools for studying the complex genetic interactions underlying Alzheimer's disease (AD) pathogenesis. The project, titled "Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models", will create a toolkit combining gene-editing...
This National Institute on Aging (NIA) Project Grant award, provided under the Aging Research federal grant program (CFDA 93.866), supports a $197,569 study led by Dr. Emily Paolillo at the University of California, San Francisco (UCSF) to investigate the utility of passive smartphone monitoring to detect neurobehavioral impairment in neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The overarching goal is to evaluate whether smartphone-based digital assessment tools...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $791,086 aims to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes, such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The project will leverage data from autopsy-confirmed datasets, in vivo neuroimaging, and clinical assessments to build...
This federal Project Grant award, valued at $131,027.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University. The award aims to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Conducting in vivo experiments using a novel bioorthogonal non-canonical amino acid tagging (BONCAT)...
This Project Grant award of $762,636 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports the development of interpretable machine learning methods for analyzing Alzheimer's disease genetics. The research aims to improve understanding of the complex genetic basis of Alzheimer's disease and identify novel therapeutic targets. Key objectives include applying advanced machine learning techniques to large-scale genetic and multi-omics datasets, while...