Project Grant R01HL181257
- This Project Grant award of $784,362.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc., will support research investigating the role of body composition, coronary microvascular dysfunction, and heart failure with preserved ejection fraction in characterizing adverse cardiometabolic disease phenotypes. The research aims to leverage novel imaging technologies to identify mechanisms of...
- The University of Utah was awarded a $756,947 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on March 10, 2025. The project aims to improve and better understand the factors that influence spin-locking cardiac MRI for assessing myocardial fibrosis, a key indicator of cardiovascular disease. The key objectives are to: 1) study the value of different T1rho MRI methods and conventional techniques in preclinical models of diffuse and...
- This federal Project Grant award of $169,020.00 was provided by the National Heart Lung and Blood Institute (NHLBI), which operates under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pennsylvania investigating the impact of obesity and diabetes on coronary microvascular defects in heart failure with preserved ejection fraction (HFpEF). The research will use an animal model of HFpEF to compare the temporal progression...
- This $702,534 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Texas A&M Engineering Experiment Station (Tees) to develop an integrated super-resolution cardiac magnetic resonance imaging-deep learning (CMR-DL) technology. The goal is to isolate and quantify the contributions of passive and active mechanisms to impaired left ventricular relaxation, a key driver of left ventricular diastolic dysfunction...
- The federal Project Grant award of $726,452 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to model intra- and inter-cellular networks involved in TRPC6-dependent cardiac fibrosis. The award aims to leverage computational methods and multi-scale experiments to better understand how TRPC6 signaling drives myofibroblast transformation and fibrosis in response to cardiac and dermal wounds. The research will be conducted by the...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $783,801 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The grant, titled "Demonstrating the Feasibility of Democratized Push-Button Autonomous Cardiac MRI Exam in Community Family Health Centers (AutoCMR for FHC)", aims to demonstrate the feasibility of using a push-button, time-resolved 3D...
- The National Heart, Lung, and Blood Institute (NHLBI), a part of the National Institutes of Health (NIH), awarded a $699,133 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Los Angeles (UCLA) to conduct research on the epigenetic regulation of heart failure with preserved ejection fraction (HFPEF). The project aims to investigate the molecular insights into the actions of SGLT2 inhibitors and GLP1 agonists across the heart,...
- The University of Arizona was awarded a $735,838 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on July 15, 2025. The grant supports research into the role of hexokinase 1 (HK1) mitochondrial dislocation in the development of heart failure with preserved ejection fraction (HFpEF). The key objectives are to investigate how HK1 dislocation leads to increased protein O-GlcNAcylation in cardiac endothelial cells, and to assess...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $762,969 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to the University of Massachusetts Medical School (UMMS) for the project "The Role of Perivascular Adipose Tissue in Atherosclerotic Cardiovascular Disease (PVAT-ASCVD)". This 5-year project aims to investigate the hypothesis that perivascular adipose tissue (PVAT) in the left internal mammary artery (LIMA) exhibits a more thermogenic...
- This federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the use of NNMT inhibition to treat heart failure. The $736,089 grant supports research to determine if increased NNMT activity, leading to NAD+ deficiency, is central to the pathophysiology of both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). The...
The National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, awarded a $802,611 Project Grant to the Rector & Visitors of the University of Virginia (UVA) with a performance period from September 15, 2025 to August 31, 2029. The purpose of this grant is to develop improved cardiac MRI (CMR) methods to quantify epicardial adipose tissue (EAT) composition and demonstrate the advantages of EAT composition imaging in advancing the understanding of the relationship between EAT and heart failure with preserved ejection fraction (HFpEF), as well as for understanding mechanisms of and guiding medical therapy in HFpEF. The key products and services to be delivered under this grant include:
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $802.6k | 9/11/25 |