Project Grant R01AG092453

Award Date 6/1/25
Completion Date 3/31/30
Dollars Obligated $774K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Irvine, CA 92697, USA
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This federal Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research initiative by the Regents of the University of California, San Francisco (UCSF) to comprehensively map the impact of tau pathology on the proteome, which is expected to be mediated in part through disruptions in mRNA splicing. The research leverages AD mouse models and human iPSC tauopathy models to discover protein drivers of tauopathy and validate such drivers in...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
The National Institute on Aging (NIA) awarded a $1,709,482 Project Grant (CFDA 93.866 - Aging Research) to the Seattle Institute for Biomedical and Clinical Research to investigate how the SUT-6/NIPP1 protein regulates pathological tau in Alzheimer's disease and other neurodegenerative "tauopathies". The 5-year grant, running from Aug 1, 2024 to Apr 30, 2029, aims to: 1) define the functions of SUT-6/NIPP1 important for suppressing tau toxicity; 2) determine downstream mediators of...
This National Institute on Aging R01 Project Grant Award (CFDA 93.866 - Aging Research) provides $745,092 to the University of Virginia to conduct research on the epitranscriptomic mechanisms underlying the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The key objectives are to: 1) Decode the epitranscriptomic profiles impacted by tau pathology using m6A DART-seq, 2) Determine the role of RNA methylation in AD pathogenesis using 3D neuron-glial brain assembloids, and 3)...
This $1,592,854 project grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Illinois to investigate the molecular mechanisms underlying tau protein dysfunction in neurodegenerative tauopathies, including Alzheimer's disease and related dementias. The overarching goal is to understand how disease-related changes in tau conformation and post-translational modifications disrupt tau's normal scaffolding functions and lead to dysregulation of key...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,276,054 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the selective vulnerability of genes, cells, and neural networks in mouse tauopathy models of Alzheimer's disease (AD). The project aims to develop quantitative mathematical models to test hypotheses regarding the selective vulnerability of certain brain regions and cell types to the...
This $437,250 Project Grant award from the National Institute on Aging's Aging Research Program (CFDA 93.866) will enable researchers at the University of California, San Diego (UCSD) to develop new imaging tools to study the tau protein and its involvement in neurodegenerative diseases like Alzheimer's. The grant will fund the creation of a peptide-based fluorescent probe that can detect and measure tau in its different forms - soluble, liquid-liquid phase separated, and liquid-solid aggregated...
This federal Project Grant award of $1,118,700.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine will support research to elucidate the role of pathological tau protein in disrupting endosomal microautophagy (EMI), a critical protein degradation pathway affected in Alzheimer's disease. The research aims to determine which components of the EMI pathway are most vulnerable to tau pathology and whether restoring EMI function can...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $320,000 will fund a study on alternative polyadenylation (APA) regulation in Alzheimer's disease (AD). The research, conducted by the University of Texas Medical Branch at Galveston, aims to comprehensively profile APA transcripts and gene expression in neurons expressing wild-type and mutant tau proteins. Specifically, the study will leverage the Poly(A)-ClickSeq (PAC-Seq)...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $1,003,116 to the University of Alabama at Birmingham (UAB) to investigate the mechanisms of synaptic resilience to tau pathology in Alzheimer's disease. The study aims to identify therapeutic protein targets that can modulate tau seeding, tau-induced synaptic dysfunction, and synapse preservation. The research will focus on understanding how some individuals maintain...

The National Institute on Aging (NIA) awarded a $773,816 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Irvine to conduct a comprehensive study on the molecular mechanisms underlying aberrant protein accumulation in Alzheimer's disease-related tauopathies. The project aims to generate cell-type-specific atlases of misprocessed RNAs and proteins in mouse models and human brain tissues to identify new pathways and protein interaction networks involved in Alzheimer's disease pathogenesis. Key activities include: 1) using spatial proteo-transcriptomics to map aberrant mRNA splicing and protein products in specific brain cell types over disease progression in mouse models and human samples; and 2) leveraging bioorthogonal non-canonical amino acid tagging to examine the impact of aberrant splicing on proteome dynamics and proteinopathy development. The multidisciplinary research team expects to deliver new insights into the molecular underpinnings of Alzheimer's-related tauopathies that can inform the development of potential therapeutic interventions. The award period spans June 1, 2025 to March 31, 2030.

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