Project Grant R01AG090534

Award Date 5/1/25
Completion Date 1/31/30
Dollars Obligated $759K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Lexington, KY 40526, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to investigate the roles of cellular senescence and blood-brain barrier dysfunction in Alzheimer's disease development and progression. The key objectives are to understand how viral and bacterial infections can initiate blood-brain barrier impairment and increase inflammation, leading to accelerated Alzheimer's disease pathology. The research...
The National Institute on Aging awarded a $1,952,654 Project Grant to the University of Kentucky Research Foundation on February 1, 2022 under the Aging Research program (CFDA 93.866). The three-year grant will fund research to evaluate reduced blood-brain barrier water exchange as a potential early biomarker for vascular cognitive impairment and dementia. Specifically, the University of Kentucky will study 140 healthy older adults at baseline and follow-up to assess the relationship between...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $242,310 to Emory University to conduct research into the role of interneuron dysfunction and tau pathology in the early stages of Alzheimer's disease (AD). The key goals are to: 1) Determine how pathological tau affects the excitability of neurons, and 2) Investigate how suppression of parvalbumin-expressing interneurons influences the progression of pathological tau in excitatory neurons....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Chapman University provides $991,800.00 to conduct research on developing a blood-brain barrier (BBB) penetrating form of the protein erythropoietin (EPO) as a potential therapeutic for Alzheimer's disease (AD). The key objectives are to: Determine the optimal dose and therapeutic window for the BBB-penetrating EPO fusion protein (TFRMAB-EPO) in mouse models of AD. Assess the safety profile of chronic...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $1,003,116 will support research at the University of Alabama at Birmingham (UAB) to investigate synaptic resilience to tau protein accumulation in Alzheimer's disease. The goal is to identify protein targets and cellular pathways that can modulate tau seeding, tau-induced synaptic dysfunction, and synaptic preservation in the context of Alzheimer's pathology. This 2-year study aims to address...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $757,027 to the University of Washington to conduct research on the mechanisms underlying the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease (AD). The 5-year project, starting January 1, 2025, aims to investigate how the combination of tau and TDP-43 pathologies impairs the lysosomal autophagy pathway, which is a compensatory mechanism observed in AD. The...
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $758,744.00 to The University of Kentucky Research Foundation to conduct research on the mechanisms of blood-brain barrier dysfunction in Alzheimer's disease (AD). The project aims to:

  1. Identify the signaling pathways through which the tau protein induces barrier dysfunction;
  2. Determine how tau is transported across the blood-brain barrier; and
  3. Develop a therapeutic intervention to repair amyloid-beta and tau-induced barrier dysfunction and slow cognitive decline in AD animal models.

This innovative research seeks to provide new mechanistic insights and therapeutic strategies for addressing blood-brain barrier dysfunction, a key contributor to AD pathology and cognitive decline. The 5-year project period runs from May 1, 2025 to January 31, 2030.

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