This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $320,000 to the University of Texas Medical Branch at Galveston to conduct research on the role of tau protein and alternative polyadenylation (APA) in Alzheimer's disease. The study aims to comprehensively profile APA transcripts and gene expression in neurons expressing wild-type and mutant tau proteins, with the goal of better understanding how tau oligomerization impacts APA and...
This National Institute on Aging Federal Grant Award under the Aging Research program (CFDA 93.866) provides $385,000.00 to Wayne State University to investigate the role of local protein synthesis in tau pathology and neurodegeneration related to Alzheimer's disease. The project aims to determine how pathogenic forms of the tau protein specifically interfere with dendritic protein synthesis, which may contribute to the synaptic dysfunction observed in Alzheimer's disease. By leveraging tau...
This $2,061,909 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Weill Medical College of Cornell University supports research on tau proteostasis and chaperone complexes in tauopathies, including Alzheimer's disease. The objective is to identify molecular mechanisms regulating tau aggregation and neurodegeneration, specifically examining how two chaperone complexes - the "foldase" complex that stabilizes tau and the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $757,027 to the University of Washington to conduct research on the mechanisms underlying the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease (AD). The 5-year project, starting January 1, 2025, aims to investigate how the combination of tau and TDP-43 pathologies impairs the lysosomal autophagy pathway, which is a compensatory mechanism observed in AD. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $242,310 to Emory University to conduct research into the role of interneuron dysfunction and tau pathology in the early stages of Alzheimer's disease (AD). The key goals are to: 1) Determine how pathological tau affects the excitability of neurons, and 2) Investigate how suppression of parvalbumin-expressing interneurons influences the progression of pathological tau in excitatory neurons....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $1,003,116 will support research at the University of Alabama at Birmingham (UAB) to investigate synaptic resilience to tau protein accumulation in Alzheimer's disease. The goal is to identify protein targets and cellular pathways that can modulate tau seeding, tau-induced synaptic dysfunction, and synaptic preservation in the context of Alzheimer's pathology. This 2-year study aims to address...
This $1,118,700.00 federal Project Grant award issued by the National Institute on Aging (CFDA 93.866 Aging Research) supports research at New York University (NYU) School of Medicine to investigate the disruption of endosomal microautophagy (EMI) by pathological tau protein. The research aims to elucidate the role of tau in destabilizing EMI, a key protein degradation pathway, and determine which EMI components are most vulnerable to tau pathology. Experiments will use human-derived neural...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
This $628,702 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of the lipid sulfatide in the development of tau pathology in Alzheimer's disease and related dementias. The primary awardee, the University of Texas Health Science Center at San Antonio, will conduct extensive studies to determine if sulfatide deficiency leads to increased tau phosphorylation, aggregation, and spreading in oligodendrocytes. The...