This federal Project Grant award, with ID R21AG089503, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The $682,000 grant will fund research to investigate the influence of microglial cell depletion and repopulation on amyloid-related imaging abnormalities (ARIA) and vascular lesions in APOE4 carriers with Alzheimer's disease, following treatment with the recently FDA-approved antibody therapy aducanumab. The key products and services to be...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the adverse cerebrovascular responses to antibodies targeting beta-amyloid, a key mechanism believed to contribute to Alzheimer's disease pathology. The $2,342,415 grant awarded to the University of California, Irvine will fund a 3-year research project with the following key objectives: Examine the temporal sequence of blood-brain barrier dysfunction, myeloid cell activation, and...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $805,738 to Battelle Memorial Institute's Pacific Northwest National Laboratory to conduct research on the impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease. The key objectives are to: 1) assess how APOE isoforms affect the distribution, composition, and amyloid beta binding capabilities of brain lipoproteins, and 2)...
This federal Project Grant award, with an ID of R01AG090773, is funded by the National Institute on Aging under the Aging Research Program (CFDA 93.866). The University of California, Los Angeles (UCLA) is the prime awardee and will receive $751,442 over the period from December 15, 2024 to November 30, 2029. The goal of this project is to optimize and evaluate a brain-penetrant CRISPR-based gene editing approach to convert the Alzheimer's disease genetic risk factor APOE4 to the benign APOE3...
This $772,581 Project Grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to investigate the role of the transcription factor SOX18 in modulating neurovascular function and its potential impact on the pathogenesis of Alzheimer's disease. Key objectives include: Examining how downregulation of SOX18 in brain endothelial cells affects angiogenesis, blood-brain barrier formation, and overall neurovascular function in mice. Using human induced pluripotent stem cell...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to investigate the roles of cellular senescence and blood-brain barrier dysfunction in Alzheimer's disease development and progression. The key objectives are to understand how viral and bacterial infections can initiate blood-brain barrier impairment and increase inflammation, leading to accelerated Alzheimer's disease pathology. The research...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $437,875 to the University of California, San Diego to conduct research on neurovascular protein lifetimes in health, aging, and Alzheimer's disease. The project aims to generate a comprehensive atlas of neurovascular protein lifetimes in these conditions, with the goal of advancing the understanding of molecular mechanisms underlying neurovascular function and dysfunction associated...
This $1,024,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to reprogram endothelial cells for the prevention and treatment of Alzheimer's disease (AD) and hypertension. The award recipient, the University of South Carolina, will test the hypothesis that exacerbated endothelial-to-mesenchymal transition (EndMT) driven by endoplasmic reticulum (ER) stress and amyloid-β protein oligomers (AβO) is a key factor in the development of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $758,744.00 to The University of Kentucky Research Foundation to conduct research on the mechanisms of blood-brain barrier dysfunction in Alzheimer's disease (AD). The project aims to: Identify the signaling pathways through which the tau protein induces barrier dysfunction; Determine how tau is transported across the blood-brain barrier; and Develop a therapeutic intervention to...
The National Institute on Aging awarded a $480,536 Project Grant under the Aging Research program (CFDA 93.866) to The Jackson Laboratory to fund research aimed at improving treatment for Alzheimer's disease and related dementias (ADRD). The project will assess whether manipulating the angiopoietin/tie2 (ANG/TIE2) signaling pathway can preserve blood-brain barrier (BBB) integrity and prevent cerebrovascular dysfunction, which are major contributors to many ADRDs. The research approach involves...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Chapman University provides $991,800.00 to conduct research on developing a blood-brain barrier (BBB) penetrating form of the protein erythropoietin (EPO) as a potential therapeutic for Alzheimer's disease (AD). The key objectives are to:
Determine the optimal dose and therapeutic window for the BBB-penetrating EPO fusion protein (TFRMAB-EPO) in mouse models of AD.
Assess the safety profile of chronic TFRMAB-EPO dosing in AD mice.
Elucidate the molecular pathways modulated by TFRMAB-EPO in the AD brain.
This comprehensive preclinical research project aims to advance the development of TFRMAB-EPO as a disease-modifying therapy for AD that can provide neuroprotective and neuroregenerative effects, addressing limitations of existing AD treatments. The 5-year award period runs from June 1, 2024 to March 31, 2029.