Project Grant R01AG090523
- The National Institute on Aging (NIA) awarded a $2,552,654.85 project grant to Vanderbilt University Medical Center under the Aging Research federal grant program (CFDA 93.866) on January 1, 2025. This grant supports efforts to systematically screen and validate drug repurposing candidates for Alzheimer's disease and related dementias (AD/ADRD). The project aims to integrate genetics, transcriptomics, literature, and clinical data with advanced informatic technologies and computational...
- This Project Grant award of $1,631,690.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) supports a research project titled "Proteomic Signatures of Delirium and Long-Term Cognitive Decline in Older Cardiac Surgical Patients." The project aims to use state-of-the-art proteomics analysis to derive and validate a delirium protein signature for cardiac surgery patients, leveraging plasma samples from an ongoing...
- This $432,418 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Vanderbilt University to discover and characterize small molecule modulators of the NURR1-RXR protein complex. The goal is to develop chemical tools that can be used to study the role of NURR1-RXR in regulating neuronal function and neuroinflammation, which are implicated in neurodegenerative diseases like Alzheimer's and Parkinson's. The 2-year project will...
- This federal Project Grant award of $2,709,669 from the National Institute on Aging (Aging Research, CFDA 93.866) aims to provide rigorous evidence on the outcomes of home-based versus facility-based care for older patients with Alzheimer's disease and related dementias (AD/ADRD). The research strategy will leverage differences in the influence of physical therapists on discharge destination as a "randomizing device" to compare outcomes across almost 100 VA hospitals. This novel...
- This $318,000 federal Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) with a start date of September 17, 2024 and an end date of August 31, 2026. The grant will fund a study to investigate the epidemiology and clinical consequences of cardiometabolic medication substitution that occurs when older adults transition from acute hospital care to skilled nursing facilities (SNFs). The research aims to determine the...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) is for the research project "Impact of Hypertension and Aging on Postoperative Delirium". The $715,801 grant, awarded on June 1, 2025, supports Duke University's research to elucidate the contributions of endothelial cells and perivascular macrophages to surgery-induced neuroinflammation, blood-brain barrier disruption, and delirium-like behavior in aging and hypertension. The overarching...
- This $679,475 Project Grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a national study on the use of antiepileptic medications among patients with dementia in long-term care facilities. The study aims to understand the factors influencing clinicians' decisions to prescribe antiepileptics, as well as the intended and unintended outcomes of such use. A sub-award of undisclosed amount will go to Brown University to support this research. The findings...
- This $2,356,117 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to improve the perioperative management of patients with Alzheimer's disease and related dementias. The primary objectives are to: (1) identify the extent to which surgical patients with these conditions are at increased risk for adverse postoperative outcomes, and (2) estimate the association between various perioperative interventions and the incidence...
- This Project Grant award, with a total funding amount of $878,190.00, was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866). The grant is supporting research by the Scripps Research Institute in California to investigate a "druggable mito-nuclear feedback mechanism" that can preserve mitochondrial and synaptic function in aging and age-related dementias like Alzheimer's...
- This Project Grant award of $242,489.00 from the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866) will fund research by Vanderbilt University Medical Center to investigate the proteomic signature associated with the dual decline of both gait and cognition in older adults. The study aims to leverage a deeply phenotyped research cohort and state-of-the-art plasma proteomics techniques to determine...
This federal Project Grant award of $1,574,743.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to Vanderbilt University Medical Center (VUMC) to study the effects of serum psychotropic drug levels and drug metabolizer status on delirium duration and long-term cognition in older hospitalized patients. The research aims to identify new targets for deprescribing psychotropic medications, such as selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRI/SNRIs), that can contribute to delirium and accelerated cognitive decline, particularly in patients with pre-existing Alzheimer's disease and related dementias. The project will utilize liquid-chromatography-mass spectroscopy to measure serum psychotropic drug levels and assess the role of cytochrome P450 genotypes in identifying additional deprescribing opportunities. The award period runs from September 1, 2025 through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 8/26/25 |