This $432,418 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Vanderbilt University to discover and characterize small molecule modulators of the NURR1-RXR protein complex. The goal is to develop chemical tools that can be used to study the role of NURR1-RXR in regulating neuronal function and neuroinflammation, which are implicated in neurodegenerative diseases like Alzheimer's and Parkinson's. The 2-year project will establish biochemical and cellular assays to screen for NURR1-RXR ligands, with the successful outcomes providing a platform to identify potent, selective compounds that can be further developed as potential therapeutic candidates or research probes. This award builds on Vanderbilt's expertise in biomedical research and drug discovery, leveraging its capabilities to advance the understanding and treatment of aging-associated neurodegenerative disorders.
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