Project Grant R01AG090334
Award Date 9/1/26
Completion Date 8/31/30
Dollars Obligated $642K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Chapel Hill, NC 27599, USA
Similar Awards
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $353,457 on March 1, 2026, under the Aging Research program (CFDA 93.866) to support a feasibility pilot testing exercise interventions to mitigate hospital-associated disability in people with dementia. The recipient, a fellowship-trained geriatrician and assistant professor of medicine at UNC, will conduct training in adapting interventions for people with dementia, clinical trial methodology, and...
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $2,265,261 on July 15, 2026, under the Aging Research program (CFDA 93.866) to investigate integrin signaling mechanisms in osteoarthritis progression. The award funds basic research examining how α5β1 integrin receptor activation by fibronectin matrix degradation products initiates pathologic cellular signaling cascades that drive chronic, non-healing inflammation and progressive cartilage destruction in...
- The National Institute on Aging awarded Wake Forest University Health Sciences $1.31 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the synergistic effects of unacylated ghrelin and endurance exercise on sarcopenia and mobility loss in older adults. The research combines unacylated ghrelin (UNAG) administration with endurance exercise training to enhance mitochondrial bioenergetics and preserve neuromuscular junction integrity in aging mice....
- The National Institute on Aging, part of the National Institutes of Health, awarded $1,250,191 to the University of North Carolina at Chapel Hill on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence and experimental workflow for accelerating discovery of small-molecule modulators that influence Alzheimer's disease through microglial phagocytosis regulation. The funded work combines AI-driven computational methods with...
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $472,658 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop live-cell imaging tools that monitor biological age in real time based on age-associated DNA methylation changes. The project will engineer two classes of genetically encoded fluorescent sensors: a "ticking" global methylation epigenetic clock that continuously visualizes intranuclear 5-methylcytosine patterns,...
- The National Institute on Aging awarded the University of Texas at Arlington $142,835 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a data-driven mixed-method study examining walkability and safety risk factors affecting older adults' street engagement. The project, titled "Data-Driven Discovery of Walkability: Safety Risk Factors and Responsive Behaviors of Older Adults," addresses gaps in age-friendly built infrastructure and current roadway design...
- The National Institute on Aging awarded the University of Pittsburgh $484,635 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop in vitro aging of cartilage in a microphysiological knee joint system. The recipient will extend the "minijoint," a microphysiological system representing critical joint tissues (cartilage, bone, synovium, adipose) and using microfluidics, to recapitulate the transition of chondrocytes from young and healthy to aged and...
- The National Institute on Aging awarded Auburn University $166,152 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNA-1 in regulating pyruvate metabolism in patients with peripheral artery disease. The research addresses skeletal muscle metabolic dysfunction in PAD, a condition affecting 8–12 million Americans and 10–15 percent of the population age 65. The award supports investigation of how microRNA-1, the most abundant microRNA in skeletal...
- The National Institute on Aging awarded Drexel University $1,306,728 under the Aging Research program (CFDA 93.866) on August 1, 2026, to conduct a longitudinal, multi-site study examining how individual lifestyle, social circumstances, and neighborhood-level factors influence physical functioning trajectories in older adults across population subgroups and U.S. regions. The research leverages over 30 years of longitudinal data from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort and...
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $1,628,644 on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct GOC ADVANCE, a cluster randomized controlled trial testing a communication intervention to improve shared decision-making about goals of care for family decision-makers of nursing home residents with late-stage Alzheimer's disease and related dementias. The trial enrolls 300 participants (150 dyads per study arm)...