Project Grant R01AG091541
- The University of North Carolina at Chapel Hill (UNC-CH) received a $427,625 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop and validate a computational framework for identifying excitation-inhibition imbalances in Alzheimer's disease (AD) using multi-modal neuroimaging data. The goal is to create an innovative technique that can noninvasively detect circuit-level disruptions in brain networks associated with AD pathology, which...
- This $1,221,276 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the "In Vivo Single-Cell Analysis of Alzheimer's Disease-Associated Regulatory Elements" research project at the University of North Carolina at Chapel Hill. The project aims to develop a novel genomic platform called Single-Cell Massively Parallel Reporter Assays (SCMPRA) to investigate how Alzheimer's disease-associated regulatory elements orchestrate gene expression...
- This Project Grant award of $2,278,636.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to characterize and evaluate different nursing home clinician care models for residents with Alzheimer's disease and related dementias (ADRD). The project aims to understand the characteristics and outcomes of existing clinician care models, with a focus on the degree of co-management between nurse practitioners and physicians. The research will survey a nationally...
- The University of North Carolina at Chapel Hill (UNC-CH) received a $424,095 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop a CRISPR/Cas13 gene therapy targeting the tau protein for the treatment of Alzheimer's disease and other tauopathies. The project aims to identify and validate optimal guide RNAs to deplete specific tau isoforms in neurons, and evaluate the therapeutic potential of this approach in preclinical Alzheimer's disease mouse...
- This $680,931 Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is focused on addressing disparities in nursing home care for individuals with serious mental illness (SMI) and Alzheimer's disease/related dementias (AD/ADRD). The key objectives are to: 1) Understand the prevalence of SMI alone and SMI with comorbid AD/ADRD in nursing homes, and assess quality outcomes for these groups by race/ethnicity; and 2) Identify...
- The University of Rochester received a $1,092,079 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to study the impacts of informal family caregiving on nursing home residents with Alzheimer's disease and related dementias (ADRD), as well as the associations between state Essential Caregiver (EC) programs and caregiving outcomes during the COVID-19 pandemic. The project aims to determine how family caregiving affects the health of nursing home residents...
- This federal Project Grant award of $2,709,669 from the National Institute on Aging (Aging Research, CFDA 93.866) aims to provide rigorous evidence on the outcomes of home-based versus facility-based care for older patients with Alzheimer's disease and related dementias (AD/ADRD). The research strategy will leverage differences in the influence of physical therapists on discharge destination as a "randomizing device" to compare outcomes across almost 100 VA hospitals. This novel...
- This $2,151,878 federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research at the University of North Carolina at Chapel Hill (UNC-CH) and its subrecipient, the University of Pennsylvania, to map the causal genetic-imaging-clinical pathway for Alzheimer's disease (AD). The key products and services to be delivered through this 3-year project include: Developing robust functional connectome analysis and causal...
- This $322,286 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to advance health equity in the use of novel treatments for Alzheimer's disease and related dementias (ADRD). The primary objectives are to: Conduct focus groups with diverse individuals affected by ADRD to understand their medication decision-making processes. Design and administer discrete choice experiments to learn how different treatment attributes are...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop an efficient, innovative, and resident-centered method to identify nursing home residents with unmet palliative care needs, with a focus on those with Alzheimer's disease and related dementias. The key objectives of the $145,043 grant, awarded on September 3, 2025, are to: (1) evaluate the content and face validity and iteratively refine a palliative care screening tool; (2)...
The University of North Carolina at Chapel Hill (UNC-CH) was awarded a $843,404 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to conduct a clinical trial titled "GOC ADVANCE (Goals of Care- Addressing Variation for Alzheimer's Disease Nursing Home Care at End of Life)". The overarching goal is to improve communication and treatment decisions for late-stage Alzheimer's disease and related dementias (ADRD), particularly among Black American nursing home residents and their families. The 5-year project will randomize 16 nursing homes with >35% Black residents to the GOC ADVANCE intervention or usual care, assessing communication quality, goal concordance, and care management outcomes in 300 resident-family decision-maker dyads. The research is designed to address disparities and variation in ADRD care at the end of life through a systematic communication intervention in partnership with community advisors.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $843.4k | 9/10/25 |