Project Grant R01AG089967

Award Date 9/15/24
Completion Date 8/31/29
Dollars Obligated $507K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $386,900.00 to the University of Texas Health Science Center at Houston (UTHealth) to study the role of the circadian clock and retinoid acid receptor-related orphan receptor (ROR) proteins in regulating metabolic function and healthy aging. The key objectives are to: 1) Evaluate the impact of ROR proteins on healthspan and lifespan using mice with skeletal muscle-specific ROR knockout, 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,512 to the University of Florida to conduct research on the role of the kynurenine pathway and aryl hydrocarbon receptor (AhR) activation in age-related physical decline and muscle weakness. The 16-month project will use novel genetic mouse models to investigate whether elevated kynurenine levels and increased AhR activity in skeletal muscle are mechanistic drivers of the decline in...
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This federal Project Grant award of $507,325 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Texas Health Science Center at Houston (UTHealth) aims to investigate the role of ROR (retinoid acid receptor-related orphan receptor) nuclear receptors in regulating mitochondrial function and skeletal muscle aging.

The key objectives are to: 1) comprehensively examine age- and circadian time-dependent changes in mitochondrial activity and homeostasis in skeletal muscle driven by ROR receptors, 2) determine the circadian transcriptional and epigenetic mechanisms by which RORs regulate OXPHOS gene expression in skeletal muscle, and 3) evaluate the requisite role of RORs in circadian interventions combining timed exercise and the ROR agonist nobiletin to promote healthy aging and extend lifespan. This research will provide new insights into the function and mechanisms of RORs in skeletal muscle aging, leveraging novel genetic mouse models and circadian biology approaches.

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