The National Institute on Aging (NIA) awarded a $1,419,500 Project Grant (CFDA 93.866 - Aging Research) to the University of Southern California (USC) to understand the neural foundations of neuropsychiatric impairments, such as apathy, associated with Alzheimer's disease (AD) in mouse models. The 5-year project aims to explore cortical pathological, molecular, cellular, and transcriptional changes linked to the progression of neuropsychiatric symptoms in AD, as well as determine how cortical neuron function contributes to apathy-like deficits. By integrating multimodal data from behavior assessments, spatial transcriptomics, anatomy, pathology, and neural function, the research seeks to generate new mechanistic insights into neuropsychiatric impairments in AD, which may inform novel strategies for patient care and therapeutic approaches to mitigate the adverse impacts of these symptoms.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $702.6k | 7/17/25 | ||
| Not listed | $716.9k | 9/16/24 |