This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to study how socioeconomic mobility during adolescence impacts cognitive health and Alzheimer's disease (AD) risk in young adulthood, with a focus on sex differences. The total award amount is $769,710 with a project period from September 15, 2024 to August 31, 2029.
The primary grantee, the University of California, Los Angeles (UCLA), will pursue three key objectives: 1) Identify the impact of mobility opportunity on general cognitive ability in young adults, and test if sex moderates this relationship; 2) Establish links between mobility opportunity, inflammatory markers, and gut microbiome, and examine how sex and APOE-E4 status interact to predict these factors; and 3) Examine associations between health indicators, brain structure/function, and cognitive ability, probing sex as a moderator.
UCLA has also issued a $182,912 sub-award to the University of Southern California (USC) to support this research by providing expertise in aging-related cognition and neuropathology. Through this comprehensive investigation, the project seeks to elucidate how socioeconomic mobility in adolescence can differentially impact the development of AD risk factors in young adult males versus females.
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