The National Institute on Aging (NIA) awarded a $498,000 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Michigan State University (MSU) to investigate the mechanisms by which midlife obesity and prediabetes contribute to later-life cognitive decline. The study aims to establish the role of the cGAS/STING inflammatory pathway and microglial dysfunction in transmitting inflammatory signals within the central nervous system, leading to age-related cognitive impairment...
This Project Grant award of $2,118,030 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 20-year longitudinal study examining psychosocial risk and protective factors for cognitive functioning among middle-aged and older Black Americans. The primary awardee, the Regents of the University of Michigan, will re-interview approximately 2,600 participants from the original National Survey of American Life cohort to collect data on a range of culturally-relevant risk...
This $2,451,044 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the "Engaging Aging Minds" research project led by The Trustees of Columbia University in the City of New York. The project aims to investigate the impact of labor force participation and stimulating activities in middle and later life on cognitive aging outcomes across diverse international settings, including low- and middle-income countries (LMICs) like China,...
This $2,365,042 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports a comprehensive research study to evaluate the biological underpinnings of Alzheimer's disease and related dementias (ADRD) across the U.S. and India. The study aims to leverage harmonized data on neurodegenerative biomarkers, cognitive outcomes, and other markers to assess the interplay between biological factors, social determinants, and ADRD risk. Key...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,671 to The Ohio State University to investigate the associations of biological aging with clinical outcomes, neuroimaging findings, and immune dysregulation in people with multiple sclerosis (MS). The 5-year study, running from July 1, 2024 to June 30, 2029, aims to establish a geroscience framework for studying MS by integrating clinical, neuroimaging, and molecular mechanistic analyses....
This Project Grant award, valued at $131,813, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award will fund research by the Trustees of Boston University, doing business as Boston University Medical Campus, to quantify the effects of poverty alleviation policies, such as the Supplemental Nutrition Assistance Program (SNAP), on the prevalence and disparities of Alzheimer's disease and related dementias (AD/ADRD). The...
This federal Project Grant award K01AG086598, with a total funding amount of $123,530.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The grant supports research to develop a naturalistic paradigm for early detection of cognitive impairment in older adults. The key objectives are to: 1) identify relationships between cognitive performance, perceived stress, and psychiatric symptoms; 2) develop natural language processing...
This federal Project Grant award of $2,494,096 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research to develop an early detection and monitoring approach for cognitive changes related to Alzheimer's disease. The project aims to leverage web-based cognitive testing to capture high-resolution multi-day learning curves that may detect subtle preclinical memory changes. The primary awardee, Brigham & Women's Hospital Inc., will collaborate with New...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to characterize cognitive reserve and identify modifiable factors that promote later-life cognitive function among older adults in India, with a focus on those lacking formal education. The total funding amount is $4,444,978.00, awarded on Sep 23, 2024, with an expected completion date of Aug 31, 2027. The key objectives are to: 1) compare the contributions of brain pathology measures to...
This $169,560 Project Grant was awarded by the National Institute on Aging under the Aging Research (CFDA 93.866) program to the Regents of the University of Michigan. The grant will fund research to identify disruptions in inhibitory interneurons that contribute to neural network dysfunction in Alzheimer's disease (AD) and related dementias. Key objectives include cataloging mediators of interneuron dysfunction, developing strategies to reverse this pathology, and evaluating the impact of...