Project Grant R01AG089307

Award Date 9/3/24
Completion Date 8/31/29
Dollars Obligated $1.3M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Nebraska, USA
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This $1,473,664 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to examine the potential benefits of local heat therapy for improving skeletal muscle architecture, glycemic control, and physical function in older adults at risk for type 2 diabetes. The overall hypothesis is that local heat therapy can improve skeletal muscle characteristics, glucose tolerance, and frailty indicators, potentially providing an alternative to...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) totals $257,116 and will be performed by Purdue University from September 1, 2024 to August 31, 2026. The award will fund a randomized, double-blind, sham-controlled clinical trial to determine the effects of daily home-based leg heat therapy on exercise capacity and quality of life in 34 older women with heart failure and preserved ejection...
The National Institute on Aging (NIA) awarded a $124,875 project grant (CFDA 93.866) to the Hebrew Rehabilitation Center in Boston, MA to study the effects of the home thermal environment on the health and well-being of low-income older adults. The 5-year grant, awarded on August 1, 2024, will continuously measure the home temperature conditions of 50 low-income older adults living in subsidized housing in Boston. Participants will use wearable devices to track sleep, gait, and self-reported...
This federal Project Grant award of $211,988 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at The University of Texas Southwestern Medical Center to evaluate low-energy cooling strategies for mitigating the adverse health effects of heat waves on the elderly. The research aims to test the efficacy of skin wetting and fan use in attenuating increases in core body temperature and cardiovascular/renal...
The National Institute on Aging (NIA) awarded a 3-year, $2,561,480 Project Grant (CFDA 93.866) to Brigham & Women's Hospital to study the post-acute sequelae of SARS-CoV-2 infection (PASC) and subsequent disease progression in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) and related dementias (ADRD). The project aims to: 1) understand the epidemiology of PASC in cognitively impaired individuals; 2) examine the impacts of COVID-19 and PASC on disease...
This federal Project Grant award, titled "HEAT WAVES AND THE ELDERLY WITH COPD: REDUCING THERMAL AND CARDIOVASCULAR CONSEQUENCES", is funded by the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research. The $143,784 grant, awarded on Sep 8, 2024, aims to investigate the physiological impact of heat wave exposure on cardiovascular, pulmonary, and thermoregulatory responses in older individuals with chronic obstructive pulmonary disease...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
The federal Project Grant award of $654,367.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, awarded on January 1, 2025, supports research to investigate the neural mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 (PASC), also known as "Long COVID". The research aims to determine the relationship...
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This $1,322,854 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to determine the safety, tolerability, and efficacy of home-based lower body heat therapy in late middle-age and older adults with post-acute sequelae of SARS-CoV-2 infection (PASC).

The primary objectives are to assess whether lower body heat therapy can: 1) safely and effectively improve cognitive and physical function, 2) attenuate inflammation and improve vascular and muscle health, and 3) enhance glucose control by enhancing mitochondrial function. The research is being conducted by the University of Nebraska, with sub-awards to the University of Nebraska Medical Center and the University of Massachusetts. The project was awarded in September 2024 and is expected to run through August 2029.

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