This $804,795 Project Grant was awarded on September 18, 2024 by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding supports a comprehensive research project investigating the neural mechanisms underlying the relationship between gait and cognitive function in individuals with subjective cognitive decline and a family history of Alzheimer's disease. The project aims to determine how declines in vestibular system function and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $955,432 to The Leland Stanford Junior University to investigate the neural mechanisms underlying gait disturbances as digital biomarkers for preclinical dementia, including Alzheimer's disease and Parkinson's disease. The project aims to leverage AI and computer vision tools to integrate multi-modal brain imaging data with gait and movement data from videos, with the goal of extracting...
This Project Grant award of $835,056, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports the development of a multi-modal system of wearable biosensors and predictive analytics to enable continuous monitoring of mobility and cognitive function in older adults. The primary goals are to: Develop a system of flexible, breathable, and inconspicuous eutectogel sensor patches that can provide real-time monitoring of biophysical domains like gait, posture, heart rate,...
This $423,147 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will fund research to understand the effects of mild cognitive impairment (MCI) and Alzheimer's disease (AD) on gait function and locomotor flexibility. The project will compare split-belt treadmill adaptation, gait performance, and cognitive function between healthy older adults, those with MCI, and those with AD. Longitudinal assessments will track disease...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This Project Grant award of $309,550.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a study to develop and apply a novel "physical activity (PA) complexity" metric using accelerometer data to explore associations between PA patterns, cognitive function, and risk of Alzheimer's disease and related dementias (ADRD) in an older adult population. The key objectives are to: (1) examine the links between PA complexity, cognitive performance, and risk of...
The National Institute on Aging (NIA) awarded a $730,089 Project Grant under CFDA 93.866 (Aging Research) to Washington University in St. Louis. The purpose of this 5-year study, titled "LIFE-SPACE, ISOLATION, AND FUNCTIONAL EXPOSOME STUDY IN PRECLINICAL ALZHEIMER'S DISEASE AND COGNITIVE ENVIRONMENTS (LIFESPACE)", is to examine the use of digital markers from everyday activities, such as driving and physical activity, to identify biological indicators of preclinical Alzheimer's disease...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
The National Institute on Aging awarded a $1,198,947 Project Grant under the Aging Research program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) on September 30, 2023. The grant will fund research to investigate the neuroprotective effects of a blood-derived enzyme called GPLD1 on Alzheimer's disease pathology. Specifically, the project aims to: 1) examine the relationships between GPLD1, physical activity, immunovascular function, and cognition in older...
This federal Project Grant award of $752,589.00 from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research aims to study the relationship between pathologies in peripheral nerves and the brain, as well as the impact of brainstem pathology and synapse loss, in individuals who died with Alzheimer's disease or related dementias. The award to the University of Iowa, a major public research university, will fund a 5-year research project starting on January 1, 2025 to address the...