Project Grant K23AG080066
Award Date
8/15/24
Completion Date
4/30/29
Dollars Obligated
$161K
Federal Agency
National Institute on Aging
Awardee
Duke University (TP7EK8DZV6N5)
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Durham, NC 27710, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $673,650 aims to evaluate the hypothesis that inflamed adipose tissue contributes to blunted exercise response in skeletal muscle of older adults. The research objectives are to: Determine how adipose tissue influences skeletal muscle function and anabolic response to exercise in older adults using in vivo imaging and molecular phenotyping. Identify the molecular pathways by which abdominal...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $3,161,352 to the University of Colorado-Denver to conduct a 5-year study on the effects of aerobic exercise training on peripheral and cerebral vascular function in adults of different ages and sexes. The research aims to investigate the molecular signals and pathways that may explain the heterogeneity in vascular adaptations to exercise training, with the goal of informing...
This Project Grant award of $158,918 from the National Institute on Aging (CFDA 93.866 Aging Research) will support Vanderbilt University's research into the effects of lifestyle on immune function and molecular aging across different populations. The study will use a multi-omic approach to characterize age-related changes in gene expression, DNA methylation, and clonal hematopoiesis in subsistence-level groups like the Tsimane, Turkana, and Orang Asli, as well as urban populations in the U.S....
The National Institute on Aging (NIA) awarded a $1,545,208 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Florida Institute for Human & Machine Cognition Inc. (IHMC). The award, effective September 15, 2024 through August 31, 2029, will fund a multidimensional study to understand the factors contributing to exercise response heterogeneity in older adults. Specifically, the research will investigate how aging hallmarks such as proteostasis, mitochondrial...
This federal Project Grant award for $351,750 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to Yale University. The award will fund a 5-year research project to investigate the role of the protein NLRX1 in regulating immune system changes associated with aging. The primary goal is to elucidate the mechanisms by which decreases in NLRX1 levels contribute to age-related alterations in T cell function, including memory T cell expansion, reduced...
The National Institute on Aging (NIA) awarded a 5-year, $1,294,013 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic to study the impact of biological mechanisms of aging on response variability to resistance training in older adults. The research will conduct a randomized clinical trial to define the exercise response heterogeneity in physical function and insulin sensitivity, examining cellular senescence and DNA methylation in skeletal muscle. The project involves collaboration with...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $616,809 to the University of South Carolina to optimize a remote-based physical activity intervention for adults with total knee replacements. The primary aim is to identify which supplemental intervention components (e.g., phone coaching, progress reports to physicians, tailored modules, individualized feedback) contribute to the greatest increases in physical activity over 6 and 12...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $419,170 to the University of Maryland, College Park to study the biophysical properties of lymph nodes and how they change with aging. The researchers will use cutting-edge techniques like multiple particle tracking and Brillouin microscopy to measure the elastic, viscous, and stiffness properties of lymph nodes, and correlate these to the composition of the extracellular matrix. This work aims...
This $339,038 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports a study on the prevalence and impact of frailty in older adults with polymyalgia rheumatica (PMR). The primary objectives are to: 1) determine the association of frailty with glucocorticoid duration and prescription analgesic use in older adults with PMR, and 2) examine the association of physical therapy (PT) service utilization with glucocorticoid duration in this...
This federal Project Grant award for $147,917, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research, supports a research project to improve cardiovascular disease risk stratification in rheumatoid arthritis patients. The key objectives are: 1) To evaluate the use of high-sensitivity cardiac troponin testing and coronary artery calcium screening to better identify rheumatoid...