This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $3,845,311 to the University of California, San Diego (UCSD) to investigate the early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The project aims to better understand the convergence of risk factors, including polygenic variants and biological aging, on molecular pathways that initiate and...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $124,050.00 to The Regents of the University of California, San Francisco (UCSF) to investigate the molecular mechanisms underlying synapse loss in Alzheimer's disease (AD). The key objectives are to: 1) Determine how IL-6 and IL-11 signaling pathways affect synaptic phosphatidylserine (PS) exposure, glial synaptic engulfment, and in vivo synaptic function in AD models; and 2) Identify other...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
The National Institute on Aging (NIA) awarded a $137,895 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, Berkeley (UC Berkeley) with a project period from December 3, 2024 to July 31, 2027. The grant will fund a study to investigate how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. Specifically, the project will use positron emission tomography (PET)...
The National Institute on Aging (NIA) awarded a $4,276,054 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) on September 1, 2024. The project aims to develop mathematical models to quantitatively test and validate hypotheses regarding the selective vulnerability of genes, cells, and neural networks in mouse models of Alzheimer's disease (AD) tauopathy. The research will leverage two enabling...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $385,612 aims to integrate experimental and computational models to study prefrontal microcircuit changes during healthy aging and Alzheimer's disease progression. The research team at the University of Wyoming will use in vivo calcium imaging, computational simulation modeling, and neural decoding to directly visualize and predict microcircuit changes in the prefrontal cortex. A sub-award of an...