This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) provides $1,275,512 in funding over 2 years from June 1, 2025 to May 31, 2027. The objective is to determine how different forms of the protein progranulin (PGRN) impact the accumulation of the TDP-43 protein, which is associated with neurodegenerative diseases like Alzheimer's, frontotemporal dementia, and limbic-predominant...
This three-year, $5.782 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into single-cell characterization of frontotemporal lobar degeneration caused by mutations in the progranulin gene. The University of California, San Francisco will map the transcriptome and gene regulatory networks that define glial pathology and neuronal vulnerability in the frontal cortex and thalamus of progranulin-deficient...
This $4,893,884 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research federal grant program (CFDA 93.866). The University of Florida will lead a collaborative effort to understand the role of central and peripheral immune crosstalk in frontotemporal dementia with progranulin mutations (FTD-GRN), an Alzheimer's disease-related dementia. The University of Florida and sub-awardees the J. David Gladstone...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $2,283,888 to The Regents of the University of California, San Francisco to conduct research on defining TBK1-associated autophagy networks in neurons. The key focus is to characterize the role of the TBK1 protein kinase and its substrate optineurin in regulating selective autophagy pathways to maintain neuronal protein homeostasis and prevent neurodegeneration in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This $459,525 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Aperture Therapeutics, Inc. aims to rapidly discover a novel oligonucleotide therapeutic for direct modulation of a genetically validated target involved in pathologic neuroinflammation. The project leverages Aperture Therapeutics' high-throughput induced pluripotent stem cell (iPSC) platform with diverse genetic models of frontotemporal dementia (FTD) to provide robust functional evidence...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $305,000 in funding to the University of Florida to determine the effect of GRN knockout restricted to the striatum on motor and non-motor symptoms in mice. The research aims to elucidate the pathophysiology of motor symptoms and language deficits associated with frontotemporal dementia (FTD) caused by GRN mutations. The key research activities include examining...
The National Institutes of Health (NIH), through the National Institute on Aging (CFDA 93.866 Aging Research program), awarded a $803,111 Project Grant to The Trustees of the University of Pennsylvania. The grant, effective from December 15, 2024 to November 30, 2029, will support a comprehensive study to model and contrast the microscopic, mesoscopic and macroscopic regional progression of neuroinflammation, abnormal iron accumulation and neurodegeneration in human brain tissue from patients...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports scientific research into the neuropathological features and molecular signatures of Frontotemporal Lobar Degeneration with Transactive Response DNA-Binding Protein Type C (FTLD-TDP Type C). The $786,632 award to Northwestern University, with a performance period from December 1, 2024 to November 30, 2029, will expand on prior discoveries regarding the impact of FTLD-TDP Type C on the...
This National Institute on Aging (NIA) Project Grant award under the Aging Research program (CFDA 93.866) provides $104,164.00 to Emory University to explore the role of the TMEM106B protein in neurodegeneration. The key objectives are to: 1) determine the interaction between TMEM106B and the C9ORF72 repeat expansion, which is linked to frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS); and 2) investigate the toxicity of TMEM106B protein aggregates and their impact on...