Project Grant R01AG088083

Award Date 8/15/24
Completion Date 7/31/29
Dollars Obligated $617K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
South Carolina, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to provide an integrated view of the complex pathophysiology of knee osteoarthritis (KOA) and mechanistically investigate how physiological exercise regulates molecular circuitry in cartilage and the surrounding knee joint in the setting of KOA. The award of $639,997 supports interdisciplinary research conducted by the Spaulding Rehabilitation Hospital Corporation to test the hypotheses that...
The National Institute on Aging (NIA) awarded a $2,617,270 Project Grant under the Aging Research (CFDA 93.866) program to Wake Forest University for the "A Mobile Health Behavior Intervention to Reduce Pain and Improve Health-III (MORPH-III)" project. This 5-year study aims to test the efficacy of a remotely delivered, group-mediated weight loss and increased physical activity intervention for reducing pain and improving health outcomes in older adults with chronic osteoarthritic knee...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $1,023,154 Project Grant (R01AG084683) to the University of Colorado-Denver to evaluate the effectiveness and implementation of neuromuscular electrical stimulation (NMES) in improving rehabilitation outcomes for patients who have undergone total knee arthroplasty (TKA). The study aims to compare outcomes between patients receiving contemporary rehabilitation with NMES versus usual...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $1,800,418 Project Grant to Neuromuscular Dynamics LLC to clinically validate and enable a go-to-market strategy for their Leg Dexterity System. This patented, portable device is designed for home-based, short-latency sensorimotor neuromuscular training to help manage knee osteoarthritis (OA) through non-surgical means. The project will conduct a longitudinal, blinded trial comparing...
This Project Grant award, totaling $187,920, was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to The Hospital For Special Surgery Fund, Inc. (doing business as HSS Foundation). The goal of this 5-year project is to adapt and pilot test a digital exercise intervention called the FiTTLE Senior System for frail and pre-frail adults aged 50 and older with systemic lupus erythematosus (SLE). The project aims to: 1) adapt the existing digital...
This Project Grant award, valued at $644,152 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA program 93.846 Arthritis, Musculoskeletal and Skin Diseases Research, supports research to determine the underlying mechanisms linking aberrant gait biomechanics with the onset and progression of knee osteoarthritis (KOA). The key objectives are to: 1) establish the acute in vivo mechanistic link between sustained versus dynamic limb-level...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), aims to develop an intraoperative sensor device to comprehensively measure ligament engagement during knee arthroplasty procedures. The total funding amount is $308,927 and the award period is from June 15, 2025 to May 31, 2026. The key objectives are to: 1) Integrate a handheld ligament tensiometer into a custom joint distractor to create an innovative "distraction...
This $625,835 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to optimize aerobic fitness and functional response to exercise in older adults. The grant aims to test the efficacy of a combined high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) approach to improve peak oxygen uptake (VO2peak) and physical function in patients eligible for cardiac rehabilitation, compared to standard...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $702,964 to the University of South Carolina to implement and evaluate a clinic-to-community physical activity program called Exercise is Medicine Greenville (EIMG). The project aims to improve the implementation and reach of EIMG across 24 primary care clinics, assess patient engagement and outcomes in the 12-week community-based physical activity programs, and...
This National Institute on Aging (NIA) Project Grant award (CFDA 93.866 - Aging Research) provides $154,858 to the University of Pittsburgh to explore the associations between a novel physical activity complexity metric and cognitive function, biomarkers, and brain structure in an older adult population. The study aims to (1) examine how physical activity complexity relates to cognitive performance and risk of mild cognitive impairment and Alzheimer's disease, (2) determine if low physical...

This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $616,809 to the University of South Carolina to optimize a remote-based physical activity intervention for adults with total knee replacement. The goal is to identify the optimal combination of intervention components, including 0-4 supplemental non-automated components, to increase physical activity levels in this population. The primary aim is to determine which supplemental components contribute to the greatest increases in moderate-to-vigorous physical activity at 6 and 12 months. Secondary aims include assessing the impact on pain, physical function, and the mechanisms by which the intervention components mediate changes in physical activity. The overarching objective is to develop an optimized, scalable physical activity intervention that can be tested in a future trial and potentially implemented within healthcare systems.

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