This Project Grant award of $638,682 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the role of liquid-liquid phase separation (LLPS) of the TDP-43 protein and its interactions with mitochondria in neurodegenerative diseases. The research aims to systematically examine how LLPS regulates TDP-43 localization to mitochondria, and how this contributes to TDP-43-induced mitochondrial dysfunction and neuronal loss, using multiple cell and animal models. The findings are expected to enhance the understanding of the intricate mechanisms underlying a broad spectrum of neurodegenerative diseases, including amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, and related dementias, where TDP-43 proteinopathy is a prominent pathological hallmark. The award was granted to the University of Arizona and is set to run from August 1, 2025 through May 31, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $638.7k | 7/23/25 |