Project Grant R01AG087914

Award Date 9/15/24
Completion Date 5/31/29
Dollars Obligated $3.1M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $654,238 to The University of Texas Health Science Center at San Antonio to study the role of senescent cells in Alzheimer's disease and related dementias (ADRD). The primary goals are to: Identify molecular markers and changes in the microenvironment of senescent neurons compared to healthy neurons, with a focus on their contribution to neuronal death in brain aging and ADRD (R21 phase). Use...
This $670,324 Project Grant award from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) will support a research project titled "Social Modifiers of Primate Lifespan" at the University of Exeter in the United Kingdom. The objectives of this 5-year project are to: 1) Leverage the researchers' Bayesian life-history model, primate social network database, and epigenetic aging clock to estimate lifespans across over 70 primate species; 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $158,918 to Vanderbilt University to conduct a multi-omic study exploring the impact of lifestyle variation on immunological aging patterns. The study will focus on characterizing age-associated molecular phenotypes such as gene expression, DNA methylation, and clonal hematopoiesis in peripheral blood samples collected from subsistence-level populations (Tsimane, Turkana, Orang Asli) and a...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $687,288 will fund a comparative analysis of somatic mutational processes across primate species with diverse lifespans. The primary awardee, the University of California, Berkeley, will collaborate with researchers at the University of Cambridge and Wellcome Sanger Institute to: Generate a comprehensive atlas of somatic mutation rates, signatures, and clonal dynamics across 10 tissue...
This Project Grant award, totaling $418,364.00, was issued by the National Institute on Aging (CFDA 93.866 - Aging Research) to Wake Forest University Health Sciences to conduct a comprehensive study on lifespan and biological aging across multiple nonhuman primate (NHP) species. The key objectives are: Generate the most accurate sex-specific lifespan and age-at-death distributions for 11 biomedically-relevant NHP species, and test the influence of factors like body size, age at reproductive...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to New York University (NYU) to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to generate brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan, creating a brain microstructure age framework. This framework will then be used to evaluate the effects of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $351,750 to Yale University to investigate the role of the protein NLRX1 in age-related changes to the immune system, particularly T cell function. The 5-year project aims to elucidate how decreases in NLRX1 may contribute to the expansion of memory T cells, decreased naive T cell survival, and other age-associated T cell alterations. The research will explore the mechanisms by which NLRX1...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,128,604.00 to The University of Texas MD Anderson Cancer Center to investigate the relationships between immunosenescence, brain aging biomarkers, and cognition across non-human primate species with differing lifespans. The project aims to elucidate the role of the immune system in longevity, neurodegeneration, and cognitive decline, which may inform the development of immuno-restorative approaches to improve human health and lifespan. This 5-year award, running from September 2024 to May 2029, represents a comprehensive scientific investigation focused on understanding the biological, clinical, and social aspects of aging, with a particular emphasis on Alzheimer's disease and related dementias.

Generated 8/5/25, 3:46 AM