Project Grant R01AG087526

Award Date 8/15/24
Completion Date 4/30/28
Dollars Obligated $1.9M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Minneapolis, MN 55455, USA
Similar Awards
This $2,156,000 Project Grant award, provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), supports research to develop non-invasive methods for measuring brain oxygen, pH, and carbon dioxide levels. The goal is to better understand the relationship between cerebral blood flow, neuronal activity, and metabolic waste products, which could provide insights into loss of brain function. The research approach combines...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine provides $254,250 to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The goal is to create a brain microstructure age framework that provides insights into the processes underlying brain aging and Alzheimer's disease/related dementias (AD/ADRD). The award period runs from Sep 15, 2024 to Jun...
The Regents of the University of Minnesota will receive $4.67 million under a three-year Project Grant from the National Institute on Aging within the Department of Health and Human Services. The grant funds research under the Aging Research program (CFDA 93.866) to characterize neuroplastic changes and their relationship to emerging motor and cognitive deficits in individuals with isolated rapid eye movement sleep behavior disorder (IRBD). Over the period of performance from August 2022 through...
The National Institutes of Health National Institute on Aging awarded $4,575,712 under the Aging Research program (CFDA 93.866) to The Washington University from May 2022 to April 2025. The award will support research into white matter metabolism in the context of aging, white matter hyperintensities, and Alzheimer's disease. Investigators will apply quantitative positron emission tomography imaging techniques to measure cerebral oxygen consumption, blood flow, oxygen extraction fraction, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $354,145 to The Trustees of Columbia University in the City of New York to conduct a comprehensive longitudinal study of functional brain network changes across the mouse lifespan. The research will use awake resting-state fMRI to quantify changes in brain network organization, particularly system segregation, and relate these changes to behavior and cognition over time. Additionally,...
This $205,619 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to map the landscape of the aged human brain and model neurodegenerative diseases like Alzheimer's. The University of Washington will apply explainable AI methods to human brain datasets to identify molecular drivers of brain aging, then manipulate these drivers in human induced pluripotent stem cell (iPSC) models to generate aging phenotypes in neurons and glia. This two-phase...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This three-year, $6.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research under the Aging Research program (CFDA 93.866). The grantee, the Regents of the University of Minnesota, will assess the acute and long-term impacts of SARS-CoV-2 infection on cognitive function and neuropathology in aging and Alzheimer's disease. Specifically, the University of Minnesota researchers will test hypotheses about how the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The research will use behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand age-related shifts in motivation and neuromodulation that impact older...
The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...

The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $1,919,387 Project Grant to the Regents of the University of Minnesota to conduct research on homeostatic modeling of functional neuroimaging data in humans. The research aims to develop a novel methodology, called HOMOD, to obtain brain maps of tissue PCO2, PO2, and pH in aging. This methodology will be used to investigate the impact of reduced resting cerebral blood flow and neurovascular coupling on brain function and homeostasis in young and elderly subjects. The project will pursue calibrated fMRI and fMRS studies, with the goal of validating HOMOD and understanding how age-related changes in neurometabolic and neurovascular coupling affect the homeostasis of critical brain metabolites. The award period is from August 15, 2024 to April 30, 2028.

Generated 7/15/25, 4:36 AM