Project Grant R61AG090388

Award Date 1/15/25
Completion Date 12/31/26
Dollars Obligated $614K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Illinois, USA
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This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) provides $374,000.00 to develop and evaluate a novel chimeric antigen receptor (CAR) macrophage therapy targeting amyloid-beta aggregates for the treatment of Alzheimer's disease. The two-phase project aims to: 1) optimize the in vitro efficacy of the AB-targeting CAR macrophages and investigate their safety and central nervous system trafficking in vivo during the R61 phase; and 2) evaluate the short-...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), provides $734,778 to the Regents of the University of Minnesota to develop and evaluate genetically engineered macrophages derived from human induced pluripotent stem cells (iPSC-iMF) for treating Alzheimer's disease and related dementias. The key objectives are to: 1) Design novel chimeric antigen receptor (CAR) constructs targeting pathogenic tau protein, and 2) Utilize genome editing to...
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